Key features and details
- Rabbit polyclonal to Neurotrypsin - Catalytic domain
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Product nameAnti-Neurotrypsin antibody - Catalytic domain
DescriptionRabbit polyclonal to Neurotrypsin - Catalytic domain
SpecificityRecognizes the 875 and 834 amino acid forms of neurotrypsin. We have a range of domain specific antibodies for this target. For a full list please see all Neurotrypsin antibodies.
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Mouse, Rat, Human
Synthetic peptide based on the catalytic domain of human Neurotrypsin.
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Storage bufferpH: 7.40
Preservative: 0.05% Sodium azide
Constituents: PBS, 50% Glycerol, 2.9% Sodium chloride
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab59454 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use at an assay dependent concentration. Predicted molecular weight: 97 kDa. A recommended starting concentration for Western blots is 1/1000 when using colorimetric substrates such as BCIP/NBT and 1/5000 for chemiluminescent substrates.|
FunctionPlays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.
Tissue specificityBrain and Leydig cells of the testis.
Involvement in diseaseDefects in PRSS12 are the cause of mental retardation autosomal recessive type 1 (MRT1) [MIM:249500]. Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.
Sequence similaritiesBelongs to the peptidase S1 family.
Contains 1 kringle domain.
Contains 1 peptidase S1 domain.
Contains 4 SRCR domains.
- Information by UniProt
- BSSP 3 antibody
- BSSP3 antibody
- Leydin antibody
All lanes : Anti-Neurotrypsin antibody - Catalytic domain (ab59454) at 1/1000 dilution
Lane 1 : Tissue lysate prepared from rat testis
at 15 µl
Lane 2 : Tissue lysate prepared from rat testis
at 10 µl
Lane 3 : Tissue lysate prepared from mouse testis
at 10 µl
Lane 4 : Tissue lysate prepared from mouse testis
at 8 µl
Lane 5 : Tissue lysate prepared from mouse testis
at 6 µl
Predicted band size: 97 kDa
ab59454 has been referenced in 2 publications.
- Spendiff S et al. Denervation drives mitochondrial dysfunction in skeletal muscle of octogenarians. J Physiol 594:7361-7379 (2016). PubMed: 27619626
- Meliopoulos VA et al. MicroRNA regulation of human protease genes essential for influenza virus replication. PLoS One 7:e37169 (2012). WB ; Human . PubMed: 22606348