Product nameAnti-Neurotrypsin antibody - Catalytic domain
DescriptionRabbit polyclonal to Neurotrypsin - Catalytic domain
SpecificityRecognizes the 875 and 834 amino acid forms of neurotrypsin. We have a range of domain specific antibodies for this target. For a full list please see all Neurotrypsin antibodies.
Tested applicationsSuitable for: IHC-Fr, WBmore details
Species reactivityReacts with: Mouse, Rat, Human
Synthetic peptide based on the catalytic domain of human Neurotrypsin.
Storage instructionsShipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Storage bufferpH: 7.40
Preservative: 0.05% Sodium azide
Constituents: PBS, 50% Glycerol, 2.9% Sodium chloride
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab59454 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-Fr||Use at an assay dependent concentration.|
|WB||Use at an assay dependent concentration. Predicted molecular weight: 97 kDa. A recommended starting concentration for Western blots is 1/1000 when using colorimetric substrates such as BCIP/NBT and 1/5000 for chemiluminescent substrates.|
FunctionPlays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.
Tissue specificityBrain and Leydig cells of the testis.
Involvement in diseaseDefects in PRSS12 are the cause of mental retardation autosomal recessive type 1 (MRT1) [MIM:249500]. Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.
Sequence similaritiesBelongs to the peptidase S1 family.
Contains 1 kringle domain.
Contains 1 peptidase S1 domain.
Contains 4 SRCR domains.
- Information by UniProt
- BSSP 3 antibody
- BSSP3 antibody
- Leydin antibody
All lanes : Anti-Neurotrypsin antibody - Catalytic domain (ab59454) at 1/1000 dilution
Lane 1 : Tissue lysate prepared from rat testis
at 15 µl
Lane 2 : Tissue lysate prepared from rat testis
at 10 µl
Lane 3 : Tissue lysate prepared from mouse testis
at 10 µl
Lane 4 : Tissue lysate prepared from mouse testis
at 8 µl
Lane 5 : Tissue lysate prepared from mouse testis
at 6 µl
Predicted band size: 97 kDa
This product has been referenced in:
- Spendiff S et al. Denervation drives mitochondrial dysfunction in skeletal muscle of octogenarians. J Physiol 594:7361-7379 (2016). Read more (PubMed: 27619626) »
- Meliopoulos VA et al. MicroRNA regulation of human protease genes essential for influenza virus replication. PLoS One 7:e37169 (2012). WB ; Human . Read more (PubMed: 22606348) »