The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1 site ELISA: 1/5000.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells.
Involvement in disease
Defects in NRTN are a cause of Hirschsprung disease (HSCR) [MIM:142623]. In association with mutations of RET gene, and possibly with other loci, defects in NRTN are involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction.
Immunohistochemistry (Frozen sections) - Anti-Neurturin antibody (ab49203)Image from Liu W et al., Auris Nasus Larynx. 2013;S0385-8146(13):00188-0. Fig 5.; doi: 10.1016/j.anl.2013.07.016 with permission from Elsevier.
ab49203 staining Neurturin in Human cochleae tissue sections by Immunohistochemistry. Samples were incubated with primary antibody (1/100) for 20 hours at 4°C. Positive Neuturin immunostaining was found in the spiral ganglion cell bodies and nerve fibers. The circle indicates peripheral nerve processes, arrows point to the nerve bundles of the central processes.
Liu W et al. Possible role of gap junction intercellular channels and connexin 43 in satellite glial cells (SGCs) for preservation of human spiral ganglion neurons : A comparative study with clinical implications. Cell Tissue Res355:267-78 (2014).
Read more (PubMed: 24241398) »
Liu W & Rask-Andersen H Immunohistological analysis of neurturin and its receptors in human cochlea. Auris Nasus LarynxN/A:N/A (2013).
Read more (PubMed: 24139947) »