Overview

  • Product name
    Anti-Neutrophil Bactericidal Protein BP30 antibody
    See all Neutrophil Bactericidal Protein BP30 primary antibodies
  • Description
    Rabbit polyclonal to Neutrophil Bactericidal Protein BP30
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Recombinant fragment corresponding to Human Neutrophil Bactericidal Protein BP30 (C terminal). C-terminal 240AA
    Database link: P17213

  • Positive control
    • Jurkat, HepG2, SK-Hep1, Mouse liver and Mouse thymus cell extracts.

Properties

Applications

Our Abpromise guarantee covers the use of ab187519 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 54 kDa.
IHC-P 1/50 - 1/200.

Target

  • Function
    The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.
  • Tissue specificity
    Restricted to cells of the myeloid series.
  • Sequence similarities
    Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
  • Domain
    The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N-and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
  • Cellular localization
    Secreted. Cytoplasmic granule membrane. Membrane-associated in polymorphonuclear Leukocytes (PMN) granules.
  • Information by UniProt
  • Database links
  • Alternative names
    • Bactericidal permeability-increasing protein antibody
    • Bactericidal/permeability increasing protein antibody
    • BPI antibody
    • BPI fold containing family D, member 1 antibody
    • BPI_HUMAN antibody
    • BPIFD1 antibody
    • CAP 57 antibody
    • CAP57 antibody
    • rBPI antibody
    • Recombinant BPI holoprotein, rBPI antibody
    see all

Images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of mouse lung tissue labelling Neutrophil Bactericidal Protein BP30 with ab187519 at 1/200. Magnification: 400x.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of mouse cancer tissue labelling Neutrophil Bactericidal Protein BP30 with ab187519 at 1/200. Magnification: 400x.
  • All lanes : Anti-Neutrophil Bactericidal Protein BP30 antibody (ab187519) at 1/500 dilution

    Lane 1 : Jurkat cell extracts
    Lane 2 : HepG2 cell extracts
    Lane 3 : SK-Hep1 cell extracts
    Lane 4 : Mouse liver cell extracts
    Lane 5 : Mouse thymus cell extracts

    Predicted band size: 54 kDa

References

ab187519 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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