NF-kappaB Activation Inhibitor VI, benzoxathiole compound (ab145954)

Overview

  • Product name

    NF-kappaB Activation Inhibitor VI, benzoxathiole compound
  • Description

    Cell-permeable benzoxathiole compound that acts as an IKK-2 inhibitor
  • Alternative names

    • (Z)-6,6-dimethyl-2-(phenylimino)-6,
    • 6,6-dimethyl-2-(phenylimino)-6,7-dihydro-5H-benzo-[1,3]oxathiol-4-one
    • BOT-64
  • Biological description

    Cell-permeable benzoxathiole compound that acts as an IKK-2 inhibitor, presumably by targeting the Ser177 and/or Ser181 residues in the kinase's activation loop domain. Shown to inhibit LPS-induced NF-κB activation (IC50 = 1.0 µM) and nitrite production (IC50 = 0.7 µM) in RAW 264.7 cells in vitro and effectively prevent LPS-induced septic death in mice in vivo.

  • Purity

    > 95%
  • CAS Number

    113760-29-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    6,6-Dimethyl-2-(phenylimino)-6,7-dihydrobenzo[d][1,3]oxathiol-4(5H)-one

  • Molecular weight

    273.40
  • Molecular formula

    C15H15NO2S
  • PubChem identifier

    13925917
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO and in ethanol

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1(CC2=C(C(=O)C1)SC(=NC3=CC=CC=C3)O2)C
  • Source

    Synthetic

References

This product has been referenced in:

  • Liu Q  et al. Ginsenoside Rg1 protects against hydrogen peroxide-induced cell death in PC12 cells via inhibiting NF-?B activation. Neurochem Int 58:119-25 (2011). Read more (PubMed: 21078355) »
  • Kim BH  et al. Benzoxathiole derivative blocks lipopolysaccharide-induced nuclear factor-kappaB activation and nuclear factor-kappaB-regulated gene transcription through inactivating inhibitory kappaB kinase beta. Mol Pharmacol 73:1309-18 (2008). Read more (PubMed: 18202307) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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