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ab19870 has been referenced in 45 publications.

  • Sanajou D  et al. Reduction of renal tubular injury with a RAGE inhibitor FPS-ZM1, valsartan and their combination in streptozotocin-induced diabetes in the rat. Eur J Pharmacol 842:40-48 (2019). PubMed: 30393200
  • Wang X  et al. Astragaloside IV inhibits glucose-induced epithelial-mesenchymal transition of podocytes through autophagy enhancement via the SIRT-NF-?B p65 axis. Sci Rep 9:323 (2019). PubMed: 30674969
  • Schiaffino L  et al. Acetylation state of RelA modulated by epigenetic drugs prolongs survival and induces a neuroprotective effect on ALS murine model. Sci Rep 8:12875 (2018). PubMed: 30150770
  • Zhang ZL  et al. Bimodal Distribution of Nuclear Factor-?B Activation and Expression of Subunits in Experimental Models of Intracerebral Hemorrhage In Vivo. J Stroke Cerebrovasc Dis N/A:N/A (2018). PubMed: 30558860
  • Fan S  et al. JNK and NF-?B signaling pathways are involved in cytokine changes in patients with congenital heart disease prior to and after transcatheter closure. Exp Ther Med 15:1525-1531 (2018). WB ; Human . PubMed: 29434738
  • Zhang Z  et al. Mouse macrophage specific knockout of SIRT1 influences macrophage polarization and promotes angiotensin II-induced abdominal aortic aneurysm formation. J Genet Genomics 45:25-32 (2018). WB ; Mouse . PubMed: 29396144
  • Huang X  et al. Neutralizing negative epigenetic regulation by HDAC5 enhances human haematopoietic stem cell homing and engraftment. Nat Commun 9:2741 (2018). WB, ChIP, ICC/IF ; Human . PubMed: 30013077
  • Liu F  et al. SRSF10-mediated IL1RAP alternative splicing regulates cervical cancer oncogenesis via mIL1RAP-NF-?B-CD47 axis. Oncogene 37:2394-2409 (2018). ChIP ; Human . PubMed: 29429992
  • Fahey JM  et al. Nitric oxide antagonism to glioblastoma photodynamic therapy and mitigation thereof by BET bromodomain inhibitor JQ1. J Biol Chem 293:5345-5359 (2018). WB ; Human . PubMed: 29440272
  • Li G  et al. SIRT1 inhibits rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and inflammatory response via suppressing NF-?B pathway. Biosci Rep 38:N/A (2018). PubMed: 29784872
  • Ugwu FN  et al. Protective Effect of Unacylated Ghrelin on Compression-Induced Skeletal Muscle Injury Mediated by SIRT1-Signaling. Front Physiol 8:962 (2017). PubMed: 29225581
  • Cheng CY  et al. Host sirtuin 1 regulates mycobacterial immunopathogenesis and represents a therapeutic target against tuberculosis. Sci Immunol 2:N/A (2017). PubMed: 28707004
  • Chen T  et al. PKCe phosphorylates MIIP and promotes colorectal cancer metastasis through inhibition of RelA deacetylation. Nat Commun 8:939 (2017). PubMed: 29038521
  • Nakazawa H  et al. iNOS as a Driver of Inflammation and Apoptosis in Mouse Skeletal Muscle after Burn Injury: Possible Involvement of Sirt1 S-Nitrosylation-Mediated Acetylation of p65 NF-?B and p53. PLoS One 12:e0170391 (2017). WB ; Mouse . PubMed: 28099528
  • Zhu G  et al. Long noncoding RNA HAS2-AS1 mediates hypoxia-induced invasiveness of oral squamous cell carcinoma. Mol Carcinog N/A:N/A (2017). Human . PubMed: 28485478
  • Leus NG  et al. HDAC1-3 inhibitor MS-275 enhances IL10 expression in RAW264.7 macrophages and reduces cigarette smoke-induced airway inflammation in mice. Sci Rep 7:45047 (2017). WB ; Mouse . PubMed: 28344354
  • Deng Z  et al. The metal nanoparticle-induced inflammatory response is regulated by SIRT1 through NF-?B deacetylation in aseptic loosening. Int J Nanomedicine 12:3617-3636 (2017). WB . PubMed: 28553103
  • Zeng C  et al. Hypothermic machine perfusion ameliorates inflammation during ischemia-reperfusion injury via sirtuin-1-mediated deacetylation of nuclear factor-?B p65 in rat livers donated after circulatory death. Mol Med Rep 16:8649-8656 (2017). PubMed: 29039506
  • Yang SY  et al. Downregulation of angiotensin type 1 receptor and nuclear factor-?B by sirtuin 1 contributes to renoprotection in unilateral ureteral obstruction. Sci Rep 6:33705 (2016). PubMed: 27659793
  • Lin Q  et al. Sirtuin1 (SIRT1) Regulates Tumor Necrosis Factor-alpha (TNF-a-Induced) Aquaporin-2 (AQP2) Expression in Renal Medullary Collecting Duct Cells Through Inhibiting the NF-?B Pathway. Med Sci Monit Basic Res 22:165-174 (2016). WB ; Rat . PubMed: 27980322
  • Ma M  et al. MiR-487a Promotes TGF-ß1-induced EMT, the Migration and Invasion of Breast Cancer Cells by Directly Targeting MAGI2. Int J Biol Sci 12:397-408 (2016). WB ; Human . PubMed: 27019625
  • Wang X  et al. Resveratrol attenuates microvascular inflammation in sepsis via SIRT-1-Induced modulation of adhesion molecules in ob/ob mice. Obesity (Silver Spring) 23:1209-17 (2015). WB ; Human . PubMed: 25959124
  • Ma B  et al. WNT/ß-catenin signaling inhibits CBP-mediated RelA acetylation and expression of proinflammatory NF-?B target genes. J Cell Sci 128:2430-6 (2015). PubMed: 26021349
  • Koga T  et al. Endoplasmic Reticulum (ER) Stress Induces Sirtuin 1 (SIRT1) Expression via the PI3K-Akt-GSK3ß Signaling Pathway and Promotes Hepatocellular Injury. J Biol Chem 290:30366-74 (2015). PubMed: 26499802
  • Castellucci M  et al. IL-10 disrupts the Brd4-docking sites to inhibit LPS-induced CXCL8 and TNF-a expression in monocytes: Implications for chronic obstructive pulmonary disease. J Allergy Clin Immunol 136:781-791.e9 (2015). PubMed: 26044852
  • Nwachukwu JC  et al. Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network. Elife 3:e02057 (2014). ChIP ; Human . PubMed: 24771768
  • Lo Sasso G  et al. SIRT2 deficiency modulates macrophage polarization and susceptibility to experimental colitis. PLoS One 9:e103573 (2014). WB ; Mouse . PubMed: 25072851
  • O'Hara A  et al. p300-mediated acetylation of COMMD1 regulates its stability, and the ubiquitylation and nucleolar translocation of the RelA NF-?B subunit. J Cell Sci 127:3659-65 (2014). WB ; Human . PubMed: 25074812
  • Shinozaki S  et al. Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65. Sci Signal 7:ra106 (2014). PubMed: 25389371
  • Pais TF  et al. The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation. EMBO J 32:2603-16 (2013). WB ; Mouse . PubMed: 24013120
  • Scuto A  et al. SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-?B/STAT3 complex to its promoter in malignant lymphoid cells. Cell Death Dis 4:e635 (2013). ChIP ; Human . PubMed: 23681230
  • Kania G  et al. Innate signaling promotes formation of regulatory nitric oxide-producing dendritic cells limiting T-cell expansion in experimental autoimmune myocarditis. Circulation 127:2285-94 (2013). PubMed: 23671208
  • Lu Y  et al. Kruppel-like factor 15 is critical for vascular inflammation. J Clin Invest 123:4232-41 (2013). WB ; Mouse . PubMed: 23999430
  • Kesanakurti D  et al. Essential role of cooperative NF-?B and Stat3 recruitment to ICAM-1 intronic consensus elements in the regulation of radiation-induced invasion and migration in glioma. Oncogene 32:5144-55 (2013). WB, IP ; Human . PubMed: 23178493
  • Kim JW  et al. New Molecular Bridge between RelA/p65 and NF-?B Target Genes via Histone Acetyltransferase TIP60 Cofactor. J Biol Chem 287:7780-91 (2012). WB, ChIP . PubMed: 22249179
  • Yang H  et al. SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-?B activity. PLoS One 7:e46364 (2012). IP ; Human . PubMed: 23029496
  • Breitenstein A  et al. Sirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells. Cardiovasc Res 89:464-72 (2011). WB ; Human . PubMed: 20978007
  • Herranz D  et al. Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer. Nat Commun 1:3 (2010). PubMed: 20975665
  • Rothgiesser KM  et al. SIRT2 regulates NF-?B dependent gene expression through deacetylation of p65 Lys310. J Cell Sci 123:4251-8 (2010). PubMed: 21081649
  • Choo QY  et al. Histone deacetylase inhibitors MS-275 and SAHA induced growth arrest and suppressed lipopolysaccharide-stimulated NF-kappaB p65 nuclear accumulation in human rheumatoid arthritis synovial fibroblastic E11 cells. Rheumatology (Oxford) 49:1447-60 (2010). WB, IP ; Human . PubMed: 20421217
  • Stein S  et al. SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice. Aging (Albany NY) 2:353-60 (2010). WB ; Human . PubMed: 20606253
  • Bourguignon LY  et al. Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates beta-catenin signaling and NFkappaB-specific transcription activity leading to MDR1 and Bcl-xL gene expression and chemoresistance in breast tumor cells. J Biol Chem 284:2657-71 (2009). WB ; Human . PubMed: 19047049
  • Lee H  et al. Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors. Cancer Cell 15:283-93 (2009). WB ; Mouse . PubMed: 19345327
  • Dai Y  et al. Interactions between bortezomib and romidepsin and belinostat in chronic lymphocytic leukemia cells. Clin Cancer Res 14:549-58 (2008). WB . PubMed: 18223231
  • Lou H & Kaplowitz N Glutathione depletion down-regulates tumor necrosis factor alpha-induced NF-kappaB activity via IkappaB kinase-dependent and -independent mechanisms. J Biol Chem 282:29470-81 (2007). WB ; Mouse . PubMed: 17690092

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