Overview

  • Product name

    NF023, competitive P2X1receptor antagonist
  • Description

    Competitive P2X1 receptor antagonist
  • Biological description

    Suramin analog and subtype-selective competitive antagonist at P2X1 receptors (IC50 values are 0.21, 28.9, >50 and >100 μM for human P2X1, P2X3, P2X2, and P2X4-mediated responses, respectively). Inhibits contraction induced by electrical field stimulation in smooth muscle.
  • Purity

    > 96%
  • CAS Number

    104869-31-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    8,8'-[Carbonylbis(imino-3,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt
  • Molecular weight

    1162.86
  • Molecular formula

    C35H20N4Na6O21S6
  • PubChem identifier

    4465
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    O=S(=O)(O[Na])c1cc(cc2c1c(ccc2S(=O)(=O)O[Na])NC(=O)c3cc(ccc3)NC(=O)Nc4cccc(c4)C(=O)Nc6ccc(c5cc(cc(c56)S(=O)(=O)O[Na])S(=O)(=O)O[Na])S(=O)(=O)O[Na])S(=O)(=O)O[Na]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Cho YR  et al. P2X and P2Y Receptors Mediate Contraction Induced by Electrical Field Stimulation in Feline Esophageal Smooth Muscle. Korean J Physiol Pharmacol 14:311-6 (2010). Read more (PubMed: 21165330) »
  • Soto F  et al. Antagonistic properties of the suramin analogue NF023 at heterologously expressed P2X receptors. Neuropharmacology 38:141-9 (1999). Read more (PubMed: 10193905) »
  • Ralevic V & Burnstock G Receptors for purines and pyrimidines. Pharmacol Rev 50:413-92 (1998). Read more (PubMed: 9755289) »

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