Anti-NFkB Inducing Kinase NIK antibody - N-terminal (ab137671)

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Overview

  • Product name

    Anti-NFkB Inducing Kinase NIK antibody - N-terminal
    See all NFkB Inducing Kinase NIK primary antibodies

  • Description

    Rabbit polyclonal to NFkB Inducing Kinase NIK - N-terminal

  • Host species

    Rabbit

  • Tested applications

    Suitable for: WBmore details

  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat

  • Immunogen

    Recombinant fragment, corresponding to a region within N terminal amino acids 1-213 of Human NFkB Inducing Kinase NIK (Uniprot ID: Q99558).

  • Positive control

    • A431, H1299, HeLa, HepG2, MOLT4 and Raji whole cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab137671 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 104 kDa.

Target

  • Function

    Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.

  • Tissue specificity

    Weakly expressed in testis, small intestine, spleen, thymus, peripheral blood leukocytes, prostate, ovary and colon.

  • Sequence similarities

    Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
    Contains 1 protein kinase domain.

  • Post-translational
    modifications

    Autophosphorylated. Phosphorylation at Thr-559 is required to activates its kinase activity and 'Lys-63'-linked polyubiquitination. Phosphorylated by CHUK/IKKA leading to MAP3K14 destabilization.
    Ubiquitinated. Undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination. 'Lys-48'-linked polyubiquitination leads to its degradation by the proteasome, while 'Lys-63'-linked polyubiquitination stabilizes and activates it.

  • Cellular localization

    Cytoplasm.
  • Information by UniProt

  • Database links

    see all

  • Alternative names

    • MAP3K14 antibody
    • FTDCR1B antibody
    • HS antibody
    • HsNIK antibody
    • M3K14_HUMAN antibody
    • Map3k14 antibody
    • Mitogen activated protein kinase kinase kinase 14 antibody
    • Mitogen-activated protein kinase kinase kinase 14 antibody
    • NF kappa beta inducing kinase antibody
    • NF-kappa-beta-inducing kinase antibody
    • NIK antibody
    • Serine/threonine-protein kinase NIK antibody
    see all

Images

  • Western blot - Anti-NFkB Inducing Kinase NIK antibody - N-terminal (ab137671)
    Western blot - Anti-NFkB Inducing Kinase NIK antibody - N-terminal (ab137671)
    All lanes : Anti-NFkB Inducing Kinase NIK antibody - N-terminal (ab137671) at 1/1000 dilution

    Lane 1 : H1299 whole cell lysate
    Lane 2 : HepG2 whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 104 kDa



    7.5% SDS PAGE

References

ab137671 has not yet been referenced specifically in any publications.

Publishing research using ab137671? Please let us know so that we can cite the reference in this datasheet.

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