Overview

  • Product name

  • Description

    Sheep polyclonal to NGF
  • Host species

    Sheep
  • Specificity

    Specificity was demonstrated by ELISA which showed there was less than 1% cross-reactivity against recombinant human Brain Derived Neurotrophic Factor (BDNF) and Neurotrophin 4 (NT4). There was approximately 2% cross reactivity with Neurotrophin 3 (NT3).
  • Tested applications

    Suitable for: WB, ELISA, Inhibition Assay, IHC-Frmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Native mouse salivary gland NGF with a purity greater than 95%.

Properties

Applications

Our Abpromise guarantee covers the use of ab49205 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 10 µg/ml. Predicted molecular weight: 27 kDa.
ELISA Use a concentration of 1 - 10 µg/ml.
Inhibition Assay Use at an assay dependent dilution. Use neat for in vivo animal studies at 2-10 ug/g body weight (ED50).
IHC-Fr Use a concentration of 1 - 10 µg/ml.

Target

  • Function

    Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177).
  • Involvement in disease

    Neuropathy, hereditary sensory and autonomic, 5
  • Sequence similarities

    Belongs to the NGF-beta family.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • Beta nerve growth factor antibody
    • Beta NGF antibody
    • Beta-nerve growth factor antibody
    • Beta-NGF antibody
    • HSAN5 antibody
    • MGC161426 antibody
    • MGC161428 antibody
    • Nerve growth factor (beta polypeptide) antibody
    • Nerve growth factor antibody
    • Nerve growth factor beta antibody
    • Nerve growth factor beta polypeptide antibody
    • Nerve growth factor beta subunit antibody
    • NGF antibody
    • NGF_HUMAN antibody
    • NGFB antibody
    • NID67 antibody
    see all

References

This product has been referenced in:

  • Madeo M  et al. Cancer exosomes induce tumor innervation. Nat Commun 9:4284 (2018). Read more (PubMed: 30327461) »
  • Nakano Y  et al. A nonsynonymous polymorphism in semaphorin 3A as a risk factor for human unexplained cardiac arrest with documented ventricular fibrillation. PLoS Genet 9:e1003364 (2013). IHC-Fr ; Human . Read more (PubMed: 23593010) »
See all 4 Publications for this product

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