Overview

  • Product name

    NH 125, CaMK III inhibitor
  • Description

    Potent, selective CaMK III inhibitor
  • Biological description

    Potent, selective CaMK III inhibitor (IC50 = 60 nM). Histidine protein kinase inhibitor (IC50 = 6.6 μM). Induces G1/S cell cycle arrest and apoptosis. Shows anticancer effects. Antibacterial agent in vivo.
  • Purity

    > 99%
  • CAS Number

    278603-08-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-Hexadecyl-2-methyl-3-(phenylmethyl)-1H-imidazolium iodide
  • Molecular weight

    524.57
  • Molecular formula

    C27H45IN2
  • PubChem identifier

    10436839
  • Storage instructions

    Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
  • Solubility overview

    Soluble in ethanol to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCCCCCCCCCCCCCCCN1C=C[N+](=C1C)CC2=CC=CC=C2.[I-]
  • Source

    Synthetic

References

This product has been referenced in:

  • Cheng Y  et al. Integrated regulation of autophagy and apoptosis by EEF2K controls cellular fate and modulates the efficacy of curcumin and velcade against tumor cells. Autophagy 9:208-19 (2013). Read more (PubMed: 23182879) »
  • Devkota AK  et al. Investigating the kinetic mechanism of inhibition of elongation factor 2 kinase by NH125: evidence of a common in vitro artifact. Biochemistry 51:2100-12 (2012). Read more (PubMed: 22352903) »
  • Chen Z  et al. 1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor. J Biol Chem 286:43951-8 (2011). Read more (PubMed: 22020937) »

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