Overview

  • Product name

  • Description

    Rabbit polyclonal to NHE-6
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide corresponding to Human NHE-6 aa 543-592 (internal sequence).

  • Positive control

    • COLO205 cell lysate
  • General notes

    Previously labelled as SLC9A6. 

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer

    pH: 7.40
    Preservative: 0.02% Sodium azide
    Constituents: 49% PBS, 50% Glycerol, 0.88% Sodium chloride
    Note: PBS is without Mg2+ and Ca2+.
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab137185 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 74 kDa.

Target

  • Function

    Electroneutral exchange of protons for Na(+) and K(+) across the early and recycling endosome membranes. Contributes to calcium homeostasis.
  • Tissue specificity

    Ubiquitous; but is most abundant in mitochondrion-rich tissues such as brain, skeletal muscle and heart.
  • Involvement in disease

    Defects in SLC9A6 are the cause of mental retardation syndromic X-linked Christianson type (MRXSC) [MIM:300243]; also known as MRXS-Christianson or X-linked Angelman-like syndrome. The phenotype is characterized by profound mental retardation, epilepsy, ataxia, and microcephaly, and showed phenotypic overlap with Angelman syndrome.
  • Sequence similarities

    Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
  • Cellular localization

    Endosome membrane. Is present in the recycling compartments including early and recycling endosomes, and only appears transiently on the plasma membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • 3732426M05 antibody
    • 6430520C02Rik antibody
    • KIAA0267 antibody
    • mKIAA0267 antibody
    • MRSA antibody
    • Na(+)/H(+) exchanger 6 antibody
    • NHE-6 antibody
    • NHE6 antibody
    • OTTHUMP00000024089 antibody
    • OTTHUMP00000024090 antibody
    • RGD1563582 antibody
    • RP11-274K13.1 antibody
    • RP23-105E2.4 antibody
    • SL9A6_HUMAN antibody
    • SLC9A6 antibody
    • Sodium/hydrogen exchanger 6 antibody
    • Solute carrier family 9 (sodium/hydrogen exchanger), isoform 6 antibody
    • Solute carrier family 9 (sodium/hydrogen exchanger), member 6 antibody
    • Solute carrier family 9 member 6 antibody
    • solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 antibody
    see all

Images

  • Anti-NHE-6 antibody (ab137185) at 1/500 dilution + COLO205 cell lysate at 30 µg

    Predicted band size: 74 kDa

References

This product has been referenced in:

  • Lucien F  et al. Hypoxia-induced mobilization of NHE6 to the plasma membrane triggers endosome hyperacidification and chemoresistance. Nat Commun 8:15884 (2017). Read more (PubMed: 28635961) »
See 1 Publication for this product

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