Key features and details
- Rabbit polyclonal to NHLRC1/Malin
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-NHLRC1/Malin antibody
See all NHLRC1/Malin primary antibodies
DescriptionRabbit polyclonal to NHLRC1/Malin
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Fusion protein within Human NHLRC1/Malin. The exact sequence is proprietary. The identity of the protein fusion partner is GST.
Database link: Q6VVB1
- WB - Lo2 cell line lysate
This product was previously labelled as NHLRC1
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Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.40
Preservative: 0.05% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab215356 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/200 - 1/1000. Predicted molecular weight: 42 kDa.|
FunctionE3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway.
Tissue specificityExpressed in brain, cerebellum, spinal cord, medulla, heart, liver, skeletal muscle and pancreas.
PathwayProtein modification; protein ubiquitination.
Involvement in diseaseEpilepsy, progressive myoclonic 2
Sequence similaritiesContains 6 NHL repeats.
Contains 1 RING-type zinc finger.
DomainThe RING domain is essential for ubiquitin E3 ligase activity.
Cellular localizationEndoplasmic reticulum. Nucleus. Localizes at the endoplasmic reticulum and, to a lesser extent, in the nucleus.
- Information by UniProt
- bA204B7.2 antibody
- E3 ubiquitin-protein ligase NHLRC1 antibody
- EPM2A antibody
ab215356 has not yet been referenced specifically in any publications.