Overview

  • Product name

    Nicaraven, Antioxidant agent
  • Description

    Antioxidant agent. Hydroxyl radical scavenger.
  • Biological description

    Antioxidant agent. Hydroxyl radical scavenger. Decreases radiation-induced IL-6 and TNF-α release. Shows anti-inflammatory, neuroprotective and anti-ischemic effects in vivo.
  • Purity

    > 99%
  • CAS Number

    79455-30-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-[2-(Pyridine-3-carbonylamino)propyl]pyridine-3-carboxamide
  • Molecular weight

    284.31
  • Molecular formula

    C15H16N4O2
  • PubChem identifier

    71234
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM, in ethanol to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(CNC(=O)C1=CN=CC=C1)NC(=O)C2=CN=CC=C2
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Kawakatsu M  et al. Nicaraven attenuates radiation-induced injury in hematopoietic stem/progenitor cells in mice. PLoS One 8:e60023 (2013). Read more (PubMed: 23555869) »
  • Zingarelli B  et al. Effects of nicaraven on nitric oxide-related pathways and in shock and inflammation. Shock 13:126-34 (2000). Read more (PubMed: 10670842) »
  • Alam MS  et al. Hydroxyl radical scavenging effect of nicaraven in myocardial and coronary endothelial preservation and reperfusion injury. Cardiovasc Res 33:686-92 (1997). Read more (PubMed: 9093540) »

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