Overview

  • Product name

    Nicardipine, L-type Ca2+ channel blocker
  • Description

    Potent L-type Ca2+ channel blocker
  • Biological description

    Potent L-type Ca2+ channel blocker. Alters cytochrome P-450 3A (CYP3A4) expression in rat livers. Elastase inhibitor (IC50= 16μM in humans and 18μM in rat). Active in vivo and in vitro.
  • Purity

    > 98%
  • CAS Number

    55985-32-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-O-[2-[Benzyl(methyl)amino]ethyl] 3-O-methyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • Molecular weight

    479.52
  • Molecular formula

    C26H29N3O6
  • PubChem identifier

    4474
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=C(C(C(=C(N1)C)C(=O)OCCN(C)CC2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OC
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Kouoh F  et al. Antioxidant effects and anti-elastase activity of the calcium antagonist nicardipine on activated human and rabbit neutrophils--a potential antiatherosclerotic property of calcium antagonists? Cardiovasc Drugs Ther 16:515-20 (2002). Read more (PubMed: 12766385) »
  • Whiting RL  et al. An overview of the pharmacology and pharmacokinetics of nicardipine. Angiology 41:987-91 (1990). Read more (PubMed: 2248427) »
  • Turlapaty P  et al. Nicardipine, a new intravenous calcium antagonist: a review of its pharmacology, pharmacokinetics, and perioperative applications. J Cardiothorac Anesth 3:344-55 (1989). Read more (PubMed: 2520662) »

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