Overview

  • Product name

    Nicorandil, ATP-sensitive K+ channel activator
  • Description

    ATP-sensitive K+ channel activator
  • Biological description

    ATP-sensitive K+ channel activator (EC50 values are 10 and 500 μM for SUR2A and SUR2B containing subtypes respectively). Shows vasodilatory effects in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    65141-46-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-(Pyridine-3-carbonylamino)ethyl nitrate
  • Molecular weight

    211.17
  • Molecular formula

    C8H9N3O4
  • PubChem identifier

    47528
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 10 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CN=CC(=C1)C(=O)NCCO[N+]([O-])=O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Chowdhury UR  et al. ATP-sensitive potassium (K(ATP)) channel openers diazoxide and nicorandil lower intraocular pressure in vivo. Invest Ophthalmol Vis Sci 54:4892-9 (2013). Read more (PubMed: 23778875) »
  • Davie CS & Standen NB Enhancement of the vasorelaxant potency of nicorandil by metabolic inhibition and adenosine in the pig coronary artery. Cardiovasc Res 37:791-8 (1998). Read more (PubMed: 9659464) »
  • Shindo T  et al. SUR2 subtype (A and B)-dependent differential activation of the cloned ATP-sensitive K+ channels by pinacidil and nicorandil. Br J Pharmacol 124:985-91 (1998). Read more (PubMed: 9692785) »

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