Product nameAnti-Nicotinic Acetylcholine Receptor alpha 5 antibody
See all Nicotinic Acetylcholine Receptor alpha 5 primary antibodies
DescriptionRabbit polyclonal to Nicotinic Acetylcholine Receptor alpha 5
SpecificityAntiserum Specificity Polypeptide % Cross Reactivity Nicotinic a5 receptor (460-468) 100%, Nicotinic a5 receptor ~95%, Nicotinic a3 receptor 0%, Nicotinic a4 receptor 0%, Nicotinic a7 receptor 0%, Nicotinic ß2 receptor 0%, Nicotinic ß3 receptor 0%, Nicotinic ß4 receptor 0%.
Tested applicationsSuitable for: ICC/IF, ELISA, WBmore details
Species reactivityReacts with: Human, Chimpanzee, Monkey
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferConstituents: PBS, 1% BSA
Our Abpromise guarantee covers the use of ab41173 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/1600. Predicted molecular weight: 53 kDa.
With this antibody, we have found that blocking with 5% goat or donkey serum significantly reduces background as compared to BSA or milk.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionAfter binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Sequence similaritiesBelongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-5/CHRNA5 sub-subfamily.
Cellular localizationCell junction > synapse > postsynaptic cell membrane. Cell membrane.
- Information by UniProt
- Acetylcholine receptor nicotinic alpha 5 (neuronal) antibody
- ACHA5_HUMAN antibody
- AChR antibody
This product has been referenced in:
- Calleja-Macias IE et al. Cholinergic signaling through nicotinic acetylcholine receptors stimulates the proliferation of cervical cancer cells: an explanation for the molecular role of tobacco smoking in cervical carcinogenesis? Int J Cancer 124:1090-6 (2009). WB ; Human . Read more (PubMed: 19048619) »