Anti-Nicotinic Acetylcholine Receptor alpha 7 antibody (ab110851)
- Datasheet
- Specific References
- Protocols
Overview
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Product nameAnti-Nicotinic Acetylcholine Receptor alpha 7 antibody
See all Nicotinic Acetylcholine Receptor alpha 7 primary antibodies -
DescriptionGoat polyclonal to Nicotinic Acetylcholine Receptor alpha 7
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Host speciesGoat
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Tested applicationsSuitable for: IHC-Pmore details
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Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat, Chicken, Cow, Dog, Pig
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Immunogen
Synthetic peptide corresponding to Human Nicotinic Acetylcholine Receptor alpha 7 aa 346-361.
Sequence:KRPGEDKVRPACQHKQ
Database link: P36544 -
Positive control
- Human Brain cortex tissue.
Properties
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FormLiquid
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term.
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Storage bufferpH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 99.48% Tris buffered saline, 0.5% BSA -
Concentration information loading... -
PurityProtein G purified
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ClonalityPolyclonal
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IsotypeIgG
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Research areas
Associated products
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Compatible Secondaries
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Positive Controls
Applications
Our Abpromise guarantee covers the use of ab110851 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P | Use a concentration of 3 - 6 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target
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FunctionAfter binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
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Sequence similaritiesBelongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-7/CHRNA7 sub-subfamily.
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Cellular localizationCell junction > synapse > postsynaptic cell membrane. Cell membrane.
- Information by UniProt
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Database links
- Entrez Gene: 374001 Chicken
- Entrez Gene: 282178 Cow
- Entrez Gene: 488696 Dog
- Entrez Gene: 1139 Human
- Entrez Gene: 11441 Mouse
- Entrez Gene: 100415931 Pig
- Entrez Gene: 25302 Rat
- Omim: 118511 Human
see all -
Alternative names
- 7nAChR antibody
- a7 nicotinic acetylcholine receptor antibody
- acetylcholine receptor, neuronal nicotinic, alpha-7 subunit antibody
see all
Images
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Nicotinic Acetylcholine Receptor alpha 7 antibody (ab110851)ab110851 at 5µg/ml staining Nicotinic Acetylcholine Receptor alpha 7 in Formalin-fixed, Paraffin-embedded Human Brain cortex tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.
Protocols
References
ab110851 has not yet been referenced specifically in any publications.
Customer reviews and Q&As
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"