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Neuroscience Neurotransmission Receptors / Channels Ligand-Gated Ion Channels nAch Receptors
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Anti-Nicotinic Acetylcholine Receptor alpha 7 antibody (ab110851)

  • Datasheet
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Nicotinic Acetylcholine Receptor alpha 7 antibody (ab110851)

    Key features and details

    • Goat polyclonal to Nicotinic Acetylcholine Receptor alpha 7
    • Suitable for: IHC-P
    • Reacts with: Human
    • Isotype: IgG

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    Overview

    • Product name

      Anti-Nicotinic Acetylcholine Receptor alpha 7 antibody
      See all Nicotinic Acetylcholine Receptor alpha 7 primary antibodies
    • Description

      Goat polyclonal to Nicotinic Acetylcholine Receptor alpha 7
    • Host species

      Goat
    • Tested Applications & Species

      Application Species
      IHC-P
      Human
      See all applications and species data
    • Immunogen

      Synthetic peptide corresponding to Human Nicotinic Acetylcholine Receptor alpha 7 aa 300-400.
      Database link: P36544

      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
    • Positive control

      • Human Brain cortex tissue.

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term.
    • Storage buffer

      pH: 7.30
      Preservative: 0.02% Sodium azide
      Constituents: 99.48% Tris buffered saline, 0.5% BSA
    • Concentration information loading...
    • Purity

      Protein G purified
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Neuroscience
      • Neurotransmission
      • Receptors / Channels
      • Ligand-Gated Ion Channels
      • nAch Receptors
      • Cancer
      • Cancer Metabolism
      • Response to hypoxia
      • Metabolism
      • Pathways and Processes
      • Metabolism processes
      • Hypoxia
      • Metabolism
      • Types of disease
      • Cancer

    Associated products

    • Compatible Secondaries

      • Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (ab150129)
      • Donkey Anti-Goat IgG H&L (HRP) (ab205723)
    • Isotype control

      • Goat IgG, polyclonal - Isotype Control (ab37373)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab110851 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Guaranteed

    Tested applications are guaranteed to work and covered by our Abpromise guarantee.

    Predicted

    Predicted to work for this combination of applications and species but not guaranteed.

    Incompatible

    Does not work for this combination of applications and species.

    Application Species
    IHC-P
    Human
    All applications
    Mouse
    Rat
    Chicken
    Cow
    Dog
    Pig
    Application Abreviews Notes
    IHC-P
    Use a concentration of 3 - 6 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
    Notes
    IHC-P
    Use a concentration of 3 - 6 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

    Target

    • Function

      After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
    • Sequence similarities

      Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-7/CHRNA7 sub-subfamily.
    • Cellular localization

      Cell junction > synapse > postsynaptic cell membrane. Cell membrane.
    • Target information above from: UniProt accession P36544 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 374001 Chicken
      • Entrez Gene: 282178 Cow
      • Entrez Gene: 488696 Dog
      • Entrez Gene: 1139 Human
      • Entrez Gene: 11441 Mouse
      • Entrez Gene: 100415931 Pig
      • Entrez Gene: 25302 Rat
      • Omim: 118511 Human
      • SwissProt: P22770 Chicken
      • SwissProt: P54131 Cow
      • SwissProt: P36544 Human
      • SwissProt: P49582 Mouse
      • SwissProt: Q05941 Rat
      • Unigene: 511772 Human
      • Unigene: 113464 Mouse
      • Unigene: 9698 Rat
      see all
    • Alternative names

      • 7nAChR antibody
      • a7 nicotinic acetylcholine receptor antibody
      • acetylcholine receptor, neuronal nicotinic, alpha-7 subunit antibody
      • ACHA7_HUMAN antibody
      • AChR antibody
      • Acra7 antibody
      • alpha 7 neuronal nicotinic acetylcholine receptor antibody
      • alpha-7 nicotinic cholinergic receptor subunit antibody
      • alpha7 antibody
      • cholinergic receptor, neuronal nicotinic, alpha polypeptide 7 antibody
      • cholinergic receptor, nicotinic, alpha 7 (neuronal) antibody
      • cholinergic receptor, nicotinic, alpha 7 antibody
      • cholinergic receptor, nicotinic, alpha polypeptide 7 antibody
      • CHRNA7 antibody
      • CHRNA7-2 antibody
      • NACHRA7 antibody
      • neuronal acetylcholine receptor protein, alpha-7 chain antibody
      • Neuronal acetylcholine receptor subunit alpha-7 antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Nicotinic Acetylcholine Receptor alpha 7 antibody (ab110851)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Nicotinic Acetylcholine Receptor alpha 7 antibody (ab110851)
      ab110851 at 5µg/ml staining Nicotinic Acetylcholine Receptor alpha 7 in Formalin-fixed, Paraffin-embedded Human Brain cortex tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

    Protocols

    • Immunohistochemistry protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (1)

    Publishing research using ab110851? Please let us know so that we can cite the reference in this datasheet.

    ab110851 has been referenced in 1 publication.

    • Nunes NS  et al. Therapeutic ultrasound attenuates DSS-induced colitis through the cholinergic anti-inflammatory pathway. EBioMedicine 45:495-510 (2019). PubMed: 31253515

    Customer reviews and Q&As

    Show All Reviews Q&A
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    Immunocytochemistry/ Immunofluorescence abreview for Anti-Nicotinic Acetylcholine Receptor alpha 7 antibody

    Poor
    Abreviews
    Abreviews
    abreview image
    Application
    Immunocytochemistry/ Immunofluorescence
    Sample
    Mouse Cell (skin)
    Specification
    skin
    Fixative
    perfusion fixation
    Permeabilization
    Yes - Triton X 100
    Blocking step
    Serum as blocking agent for 30 minute(s) · Concentration: 5% · Temperature: 22°C
    Read More

    Abcam user community

    Verified customer

    Submitted Jan 02 2013

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