Validated using a knockout cell line
Recombinant
RabMAb

Anti-Niemann Pick C1 antibody [EPR5209] (ab134113)

Knockout Tested Rabbit recombinant monoclonal Niemann Pick C1 antibody [EPR5209]. Validated in WB, IHC, Flow Cyt, ICC/IF and tested in Mouse, Rat, Human. Cited in 11 publication(s).

Publishing research using ab134113? Please let us know so that we can cite the reference in this datasheet.

ab134113 has been referenced in 11 publications.

  • Causevic M  et al. BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains. PLoS One 13:e0200344 (2018). WB ; Mouse . PubMed: 29979789
  • Hughes MP  et al. AAV9 intracerebroventricular gene therapy improves lifespan, locomotor function and pathology in a mouse model of Niemann-Pick type C1 disease. Hum Mol Genet 27:3079-3098 (2018). PubMed: 29878115
  • Li X  et al. 3.3 Å structure of Niemann-Pick C1 protein reveals insights into the function of the C-terminal luminal domain in cholesterol transport. Proc Natl Acad Sci U S A 114:9116-9121 (2017). PubMed: 28784760
  • Munkacsi AB  et al. Normalization of Hepatic Homeostasis in the Npc1nmf164 Mouse Model of Niemann-Pick Type C Disease Treated with the Histone Deacetylase Inhibitor Vorinostat. J Biol Chem 292:4395-4410 (2017). PubMed: 28031458
  • Yang DS  et al. Cyclodextrin has conflicting actions on autophagy flux in vivo in brains of normal and Alzheimer model mice. Hum Mol Genet 26:843-859 (2017). PubMed: 28062666
  • Nelson EA  et al. The phosphatidylinositol-3-phosphate 5-kinase inhibitor apilimod blocks filoviral entry and infection. PLoS Negl Trop Dis 11:e0005540 (2017). ICC/IF ; Monkey . PubMed: 28403145
  • Vienken H  et al. Characterization of cholesterol homeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts reveals a Niemann-Pick disease type C-like phenotype with enhanced lysosomal Ca(2+) storage. Sci Rep 7:43575 (2017). WB . PubMed: 28262793
  • Cermak S  et al. Loss of Cathepsin B and L Leads to Lysosomal Dysfunction, NPC-Like Cholesterol Sequestration and Accumulation of the Key Alzheimer's Proteins. PLoS One 11:e0167428 (2016). WB, ICC/IF ; Mouse, Human, Chinese hamster . PubMed: 27902765
  • Li D  et al. An Ebola Virus-Like Particle-Based Reporter System Enables Evaluation of Antiviral Drugs In Vivo under Non-Biosafety Level 4 Conditions. J Virol 90:8720-8 (2016). PubMed: 27440895
  • Yin X  et al. Distinct Entry Mechanisms for Nonenveloped and Quasi-Enveloped Hepatitis E Viruses. J Virol 90:4232-42 (2016). PubMed: 26865708
  • Czyz DM  et al. Host-directed antimicrobial drugs with broad-spectrum efficacy against intracellular bacterial pathogens. MBio 5:e01534-14 (2014). WB . PubMed: 25073644

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