Anti-Niemann Pick C1 Like 1/NPC1L1 antibody (ab121000)

This fast track antibody is not yet fully characterized. It is subject to these terms and conditions.


  • Product name

    Anti-Niemann Pick C1 Like 1/NPC1L1 antibody
    See all Niemann Pick C1 Like 1/NPC1L1 primary antibodies
  • Description

    Goat polyclonal to Niemann Pick C1 Like 1/NPC1L1

    This product is a fast track antibody. It has been affinity purified and shows high titre values against the immunizing peptide by ELISA. Read the terms of use »

  • Host species

  • Species reactivity

    Predicted to work with: Mouse, Rat, Rabbit, Human, Cynomolgus monkey, Chinese hamster
  • Immunogen

    Synthetic peptide corresponding to Mouse Niemann Pick C1 Like 1/NPC1L1 aa 56-69 (N terminal).


    Database link: NP_997125.2

  • General notes

     This product was previously labelled as Niemann Pick C1 Like 1




Fast track antibodies constitute a diverse group of products that have been released to accelerate your research, but are not yet fully characterized. They have all been affinity purified and show high titre values against the immunizing peptide (by ELISA). Fast track terms of use

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 147 kDa. This antibody did not give bands in initial tests on lysate/cell line, we would welcome your feedback if you have tested this antibody in more suitable positive controls.


  • Function

    Play a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorbtion. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism.
  • Tissue specificity

    Widely expressed. Expressed in liver. Also expressed in small intestine, pancreas, kidney, lung, pancreas, spleen, heart, gall bladder, brain, testis, stomach and muscle.
  • Sequence similarities

    Belongs to the patched family.
    Contains 1 SSD (sterol-sensing) domain.
  • Post-translational

    Highly glycosylated.
  • Cellular localization

    Apical cell membrane. Cell membrane. Cytoplasmic vesicle membrane. Subfractionation of brush border membranes from proximal enterocytes suggests considerable association with the apical membrane fraction. Exists as a predominantly cell surface membrane expressed protein (By similarity). According to PubMed:15671032, localizes in a subcellular vesicular compartment rich in RAB5.
  • Information by UniProt
  • Database links

  • Alternative names

    • Niemann Pick C1 like protein 1 antibody
    • Niemann Pick disease type C1 gene like 1 antibody
    • Niemann-Pick C1-like protein 1 antibody
    • NPC1 LIKE 1 antibody
    • NPC1 Niemann Pick disease type C1 gene like 1 antibody
    • NPC1L1 antibody
    • NPC1L1 splice variant antibody
    • NPCL1_HUMAN antibody
    • Truncated Niemann Pick C1 like protein 1 antibody
    see all


This product has been referenced in:

  • Zhong CY  et al. Microbiota prevents cholesterol loss from the body by regulating host gene expression in mice. Sci Rep 5:10512 (2015). WB ; Mouse . Read more (PubMed: 26015368) »
See 1 Publication for this product

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