Recombinant
RabMAb

Recombinant Anti-Niemann Pick C1 Like 1/NPC1L1 antibody [EPR5717] - BSA and Azide free (ab248011)

Overview

  • Product name

    Anti-Niemann Pick C1 Like 1/NPC1L1 antibody [EPR5717] - BSA and Azide free
    See all Niemann Pick C1 Like 1/NPC1L1 primary antibodies
  • Description

    Rabbit monoclonal [EPR5717] to Niemann Pick C1 Like 1/NPC1L1 - BSA and Azide free
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: ICC/IF or IHC-P
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human Niemann Pick C1 Like 1/NPC1L1 aa 1300 to the C-terminus. The exact sequence is proprietary.

  • General notes

    ab248011 is a PBS-only buffer format of ab124801. Please refer to ab124801 for recommended dilutions, protocols, and image data.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

     

     This product was previously labelled as Niemann Pick C1 Like 1

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab248011 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Detects a band of approximately 149 kDa (predicted molecular weight: 149 kDa).
  • Application notes
    Is unsuitable for ICC/IF or IHC-P.
  • Target

    • Function

      Play a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorbtion. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism.
    • Tissue specificity

      Widely expressed. Expressed in liver. Also expressed in small intestine, pancreas, kidney, lung, pancreas, spleen, heart, gall bladder, brain, testis, stomach and muscle.
    • Sequence similarities

      Belongs to the patched family.
      Contains 1 SSD (sterol-sensing) domain.
    • Post-translational
      modifications

      Highly glycosylated.
    • Cellular localization

      Apical cell membrane. Cell membrane. Cytoplasmic vesicle membrane. Subfractionation of brush border membranes from proximal enterocytes suggests considerable association with the apical membrane fraction. Exists as a predominantly cell surface membrane expressed protein (By similarity). According to PubMed:15671032, localizes in a subcellular vesicular compartment rich in RAB5.
    • Information by UniProt
    • Database links

    • Alternative names

      • Niemann Pick C1 like protein 1 antibody
      • Niemann Pick disease type C1 gene like 1 antibody
      • Niemann-Pick C1-like protein 1 antibody
      • NPC1 LIKE 1 antibody
      • NPC1 Niemann Pick disease type C1 gene like 1 antibody
      • NPC1L1 antibody
      • NPC1L1 splice variant antibody
      • NPCL1_HUMAN antibody
      • Truncated Niemann Pick C1 like protein 1 antibody
      see all

    References

    ab248011 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab248011.
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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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