Nifekalant hydrochloride (MS-551), voltage-dependent HERG channel blocker (ab142924)

Overview

  • Product name

    Nifekalant hydrochloride (MS-551), voltage-dependent HERG channel blocker
  • Description

    Voltage-dependent HERG channel blocker
  • Biological description

    Voltage-dependent HERG channel blocker. Causes facilitation of HERG at low potentials. Type III antiarrhythmic agent. Active in vitro and in vivo.
  • Purity

    > 98%
  • CAS Number

    130656-51-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    6-[2-[2-Hydroxyethyl-[3-(4-nitrophenyl)propyl]amino]ethylamino]-1,3-dimethylpyrimidine-2,4-dione hydrochloride
  • Molecular weight

    441.91
  • Molecular formula

    C19H2712px;">N5O5.HCl
  • PubChem identifier

    122188
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN1C(=CC(=O)N(C1=O)C)NCCN(CCCC2=CC=C(C=C2)[N+](=O)[O-])CCO.Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Furutani K  et al. A mechanism underlying compound-induced voltage shift in the current activation of hERG by antiarrhythmic agents. Biochem Biophys Res Commun 415:141-6 (2011). Read more (PubMed: 22020101) »
  • Ji XF  et al. Comparison of the efficacy of nifekalant and amiodarone in a porcine model of cardiac arrest. Resuscitation 81:1031-6 (2010). Read more (PubMed: 20627529) »
  • Hosaka Y  et al. Mutational analysis of block and facilitation of HERG current by a class III anti-arrhythmic agent, nifekalant. Channels (Austin) 1:198-208 (0). Read more (PubMed: 18690032) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab142924.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up