Key features and details
- Potent and selective Bcr/Abl tyrosine kinase inhibitor
- CAS Number: 641571-10-0
- Purity: > 99%
- Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
Product nameNilotinib (AMN107), Bcr/Abl tyrosine kinase inhibitor
DescriptionPotent and selective Bcr/Abl tyrosine kinase inhibitor
Biological descriptionPotent and selective Bcr/Abl tyrosine kinase inhibitor (IC50 = 15 nM). JAK2/STAT5 inhibitor. Inhibits MDM2 at the post-translational level by inducing MDM2 self-ubiquitination and degradation. Shows antiproliferative and antitumor effects in vivo. Orally active.
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 10 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Pathways and Processes
- Metabolic signaling pathways
- Energy transfer pathways
- Energy Metabolism
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab142019 has been referenced in 1 publication.
- Sterne GR et al. Dysregulated Dscam levels act through Abelson tyrosine kinase to enlarge presynaptic arbors. Elife 4:N/A (2015). PubMed: 25988807