Niltubacin, Tubacin analog and negative control (ab144537)

Overview

  • Product name

    Niltubacin, Tubacin analog and negative control
  • Description

    Inactive Tubacin (HDAC6 inhibitor) analog and negative control
  • Biological description

    Inactive Tubacin (HDAC6 inhibitor) analog and negative control.
  • Purity

    > 99%
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    7-(4-((2R,4R,6S)-4-((4,5-Dipenyloxazol-2-ylthio)methyl)-6-(4-(hydroxymethyl)phenyl)-1,3-dioxan-2-yl)phenylcarbamoyl)heptanoic acid
  • Molecular weight

    706.85
  • Molecular formula

    C41H42N2O7S
  • PubChem identifier

    6675803
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 5 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1[C@@H](O[C@@H](O[C@@H]1C2=CC=C(C=C2)CO)C3=CC=C(C=C3)NC(=O)CCCCCCC(=O)O)CSC4=NC(=C(O4)C5=CC=CC=C5)C6=CC=CC=C6
  • Source

    Synthetic

References

This product has been referenced in:

  • Siow D & Wattenberg B The histone deacetylase-6 inhibitor tubacin directly inhibits de novo sphingolipid biosynthesis as an off-target effect. Biochem Biophys Res Commun 449:268-71 (2014). Read more (PubMed: 24835950) »
  • Chen S  et al. HDAC6 regulates mitochondrial transport in hippocampal neurons. PLoS One 5:e10848 (2010). Read more (PubMed: 20520769) »
  • Cabrero JR  et al. Lymphocyte chemotaxis is regulated by histone deacetylase 6, independently of its deacetylase activity. Mol Biol Cell 17:3435-45 (2006). Read more (PubMed: 16738306) »
See 1 Publication for this product

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