Overview

  • Product name

    Nilvadipine, L-type calcium channel blocker
  • Description

    Potent L-type calcium channel blocker
  • Biological description

    Potent L-type calcium channel blocker (IC50 = 0.03 nM). Antiantherogenic in vitro and antihypertensive in vivo.
  • Purity

    > 99%
  • CAS Number

    75530-68-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-(1-methylethyl) ester
  • Molecular weight

    385.38
  • Molecular formula

    C19H19N3O6
  • PubChem identifier

    4494
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC=1NC(C#N)=C(C(C=1C(=O)OC(C)C)c2cccc(c2)[N+]([O-])=O)C(=O)OC
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Ishida S  et al. Calcium channel blocker nilvadipine, but not diltiazem, inhibits ocular inflammation in endotoxin-induced uveitis. Jpn J Ophthalmol 54:594-601 (2010). Read more (PubMed: 21191722) »
  • Paris D  et al. Nilvadipine antagonizes both Abeta vasoactivity in isolated arteries, and the reduced cerebral blood flow in APPsw transgenic mice. Brain Res 999:53-61 (2004). Read more (PubMed: 14746921) »
  • Rosenthal J Nilvadipine: profile of a new calcium antagonist. An overview. J Cardiovasc Pharmacol 24 Suppl 2:S92-107 (1994). Read more (PubMed: 7898101) »
  • Nomoto A  et al. Antiatherogenic activity of FR34235 (Nilvadipine), a new potent calcium antagonist. Effect on cuff-induced intimal thickening of rabbit carotid artery. Atherosclerosis 64:255-61 (1987). Read more (PubMed: 3606723) »

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