Overview

  • Product name

    Nimbolide, CyclinA and ERK1/2 inhibitor
  • Description

    CyclinA and ERK1/2 inhibitor. Terpenoid lactone.
  • Biological description

    CyclinA and ERK1/2 inhibitor. Terpenoid lactone derived from Azadirachta indica. Proapoptotic and anticancer activity in vivo.
  • Purity

    > 97%
  • CAS Number

    25990-37-8
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Babykutty S  et al. Nimbolide retards tumor cell migration, invasion, and angiogenesis by downregulating MMP-2/9 expression via inhibiting ERK1/2 and reducing DNA-binding activity of NF-?B in colon cancer cells. Mol Carcinog 51:475-90 (2012). Read more (PubMed: 21678498) »
  • Gupta SC  et al. Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax. J Biol Chem 286:1134-46 (2011). Read more (PubMed: 21078664) »
  • Harish Kumar G  et al. The neem limonoids azadirachtin and nimbolide inhibit cell proliferation and induce apoptosis in an animal model of oral oncogenesis. Invest New Drugs 28:392-401 (2010). Read more (PubMed: 19458912) »

Customer reviews and Q&As

Question
Answer


The laboratory have confirmed that IC50 (can range from nM to uM concentration) values differ based on the cell type and method of analysis used. Here are some examples:

http://www.ncbi.nlm.nih.gov/pubmed/18719855

http://aac.asm.org/content/early/2014/06/05/AAC.00022-14

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