Nintedanib, triple angiokinase inhibitor (ab229183)

Overview

  • Product name

    Nintedanib, triple angiokinase inhibitor
  • Description

    Potent triple angiokinase inhibitor
  • Alternative names

    • BIBF 1120
  • Biological description

    Potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β (IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM respectively in cell-free assays). Indolinone derivative.

  • Purity

    > 99%
  • CAS Number

    928326-83-4

Properties

  • Chemical name

    (Z)-3-((4-(N-Methyl-2-(4-methylpiperazin-1-yl)acetamido)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate methyl ester
  • Molecular weight

    539.62
  • Molecular formula

    C31H33N5O4
  • PubChem identifier

    9809715
  • Storage instructions

    Shipped at 4°C. Store at -20°C. Store In the Dark. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 10 mM and in ethanol to 5 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)N/C(=C\3/C4=C(C=C(C=C4)C(=O)OC)NC3=O)/C5=CC=CC=C5
  • Source

    Synthetic

References

ab229183 has not yet been referenced specifically in any publications.

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