Overview

  • Product name

  • Description

    Rabbit polyclonal to NIPA1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Horse, Guinea pig, Cow, Cat, Dog
  • Immunogen

    Synthetic peptide corresponding to a region within C-terminal amino acids 280-329 (FREWSNVGLV DFLGMACGFT TVSVGIVLIQ VFKEFNFNLG EMNKSNMKTD) of Human NIPA1.

  • Positive control

    • 721_B cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab128640 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 35 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Function

    Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+).
  • Tissue specificity

    Widely expressed with highest levels in neuronal tissues.
  • Involvement in disease

    Defects in NIPA1 are the cause of spastic paraplegia autosomal dominant type 6 (SPG6) [MIM:600363]. Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.
  • Sequence similarities

    Belongs to the NIPA family.
  • Cellular localization

    Cell membrane. Early endosome. Recruited to the cell membrane in response to low extracellular magnesium.
  • Information by UniProt
  • Database links

  • Alternative names

    • FSP 3 antibody
    • FSP3 antibody
    • Magnesium transporter NIPA1 antibody
    • MGC102724 antibody
    • MGC35570 antibody
    • NIPA 1 antibody
    • NIPA1 antibody
    • NIPA1_HUMAN antibody
    • Non imprinted in Prader Willi/Angelman syndrome region protein 1 antibody
    • Non-imprinted in Prader-Willi/Angelman syndrome region protein 1 antibody
    • Spastic paraplegia 6 (autosomal dominant) antibody
    • Spastic paraplegia 6 protein antibody
    • SPG 6 antibody
    • SPG6 antibody
    see all

Images

  • Anti-NIPA1 antibody (ab128640) at 1 µg/ml + 721_B cell lysate at 10 µg

    Predicted band size: 35 kDa



    12% SDS PAGE

References

ab128640 has not yet been referenced specifically in any publications.

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