Nisoldipine, L-type Ca2+ channel blocker (ab143071)

Overview

  • Product name

    Nisoldipine, L-type Ca2+ channel blocker
  • Description

    L-type Ca2+ channel blocker
  • Biological description

    L-type Ca2+ channel blocker. Ca2+ antagonist and vasodilator. Cardioprotective. Active in vitro and in vivo.
  • Purity

    > 99%
  • CAS Number

    63675-72-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-O-Methyl 5-O-(2-methylpropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • Molecular weight

    388.41
  • Molecular formula

    C20H24N2O6
  • PubChem identifier

    4499
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1(=C(C(C(=C(N1)C)C(OC)=O)C2=CC=CC(=C2)[N+](=O)[O-])C(OCC(C)C)=O)C
  • Source

    Synthetic

References

This product has been referenced in:

  • Summers BA  et al. Augmentation of L-type calcium current by hypoxia in rabbit carotid body glomus cells: evidence for a PKC-sensitive pathway. J Neurophysiol 84:1636-44 (2000). Read more (PubMed: 10980033) »
  • Ehring T & Heusch G Dihydropyridine calcium antagonists: beneficial or adverse effects in the setting of myocardial ischaemia/reperfusion? Cardiology 88 Suppl 1:3-14; discussion 15-6 (1997). Read more (PubMed: 9118166) »

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