Nitazoxanide, antiparasitic and antiviral agent (ab143034)

Overview

  • Product name

    Nitazoxanide, antiparasitic and antiviral agent
  • Description

    Broad spectrum antiparasitic, antibacterial agent
  • Biological description

    Broad spectrum antiparasitic, antibacterial agent. Anti-inflammatory, low toxicity. Noncompetitively inhibits pyruvate oxidoreductase. Active in vitro and in vivo.
  • CAS Number

    55981-09-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    [2-[(5-Nitro-1,3-thiazol-2-yl)carbamoyl]phenyl]acetate
  • Molecular weight

    307.28
  • Molecular formula

    C12H9N3O5S
  • PubChem identifier

    41684
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC=CC(=C1OC(C)=O)C(NC2=NC=C(S2)[N+](=O)[O-])=O
  • Source

    Synthetic

References

This product has been referenced in:

  • Hoffman PS  et al. Antiparasitic drug nitazoxanide inhibits the pyruvate oxidoreductases of Helicobacter pylori, selected anaerobic bacteria and parasites, and Campylobacter jejuni. Antimicrob Agents Chemother 51:868-76 (2007). Read more (PubMed: 17158936) »
  • Fox LM & Saravolatz LD Nitazoxanide: a new thiazolide antiparasitic agent. Clin Infect Dis 40:1173-80 (2005). Read more (PubMed: 15791519) »

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