Overview

  • Product name

    Anti-NK-2R antibody [EPR6838(B)]
    See all NK-2R primary antibodies
  • Description

    Rabbit monoclonal [EPR6838(B)] to NK-2R
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC,IHC-P or IP
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human NK-2R aa 350-450. The exact sequence is proprietary.

  • Positive control

    • Caco-2, Human heart, HT29, K562 and HeLa cell lysates.
  • General notes

     

     

    Previously labelled as Neurokinin A Receptor. 

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab124998 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Detects a band of approximately 44 kDa (predicted molecular weight: 44 kDa).
  • Application notes
    Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • Target

    • Function

      This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.
    • Sequence similarities

      Belongs to the G-protein coupled receptor 1 family.
    • Cellular localization

      Cell membrane.
    • Information by UniProt
    • Database links

    • Alternative names

      • Neurokinin 2 receptor antibody
      • Neurokinin A receptor antibody
      • NK 2 receptor antibody
      • NK 2R antibody
      • NK-2 receptor antibody
      • NK-2R antibody
      • NK2 receptor antibody
      • NK2R antibody
      • NK2R_HUMAN antibody
      • NKNAR antibody
      • Seven transmembrane helix receptor antibody
      • SKR antibody
      • Substance K receptor antibody
      • Substance-K receptor antibody
      • TAC 2R antibody
      • TAC R2 antibody
      • TAC2R antibody
      • Tachykinin receptor 2 (substance K receptor; neurokinin 2 receptor) antibody
      • Tachykinin receptor 2 antibody
      • TACR 2 antibody
      • TACR2 antibody
      see all

    Images

    • All lanes : Anti-NK-2R antibody [EPR6838(B)] (ab124998) at 1/1000 dilution

      Lane 1 : Caco-2 cell lysate
      Lane 2 : Human heart lysate
      Lane 3 : HT29 cell lysate
      Lane 4 : K562 cell lysate
      Lane 5 : HeLa cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : Goat anti-Rabbit HRP at 1/2000 dilution

      Predicted band size: 44 kDa

    References

    This product has been referenced in:

    • Nizam E & Erin N Differential consequences of neurokinin receptor 1 and 2 antagonists in metastatic breast carcinoma cells; Effects independent of Substance P. Biomed Pharmacother 108:263-270 (2018). Read more (PubMed: 30223097) »
    • Gutierrez S & Boada MD Neuropeptide-induced modulation of carcinogenesis in a metastatic breast cancer cell line (MDA-MB-231LUC+). Cancer Cell Int 18:216 (2018). Read more (PubMed: 30598641) »
    See all 2 Publications for this product

    Customer reviews and Q&As

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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