Overview

  • Product name
    NKH 477 (Colforsin daropate)
  • Description
    Water-soluble analogue of forskolin (ab120058), an adenylyl cyclase activator
  • Alternative names
    • Colforsin daropate hydrochloride
  • Biological description
    Water-soluble adenylyl cyclase activator
  • Purity
    > 98%

Properties

References

This product has been referenced in:
  • Morinobu S  et al. Stimulation of adenylyl cyclase and induction of brain-derived neurotrophic factor and TrkB mRNA by NKH477, a novel and potent forskolin derivative. J Neurochem 72:2198-205 (1999). Read more (PubMed: 10217303) »
  • Satake K  et al. Relaxant effects of NKH477, a new water-soluble forskolin derivative, on guinea-pig tracheal smooth muscle: the role of Ca2+-activated K+ channels. Br J Pharmacol 123:753-61 (1998). Read more (PubMed: 9517396) »
  • Hosono M  et al. Cardiovascular and adenylate cyclase stimulant properties of NKH477, a novel water-soluble forskolin derivative. J Cardiovasc Pharmacol 19:625-34 (1992). Read more (PubMed: 1380607) »

Customer reviews and Q&As

1-2 of 2 Abreviews or Q&A

Answer

Thank you for your email.

This does sound like something that we would be very interested in and sounds like something that we could help with. If we were to do this, we would only ask that we were mentioned in any relevant publication, preferably mentioned as the source of the Forskolin.

Please let me know if you need anything else!

Best wishes!

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Question

We are working on a scientific project that involves new methods to generate plant terpenoid products, one of which is Forskolin. Abcam currently sell a derivative of this compound, namely:

NKH 477 (Colforsin daropate)

Product code: ab120190 (formerly Asc-190)

Our new project involves transforming plants and cyanobacteria with genes encoding cytochromes P450 that produce diterpenoids (including Forskolin) and the key point of the project is that the P450s will be targeted into the chloroplast and driven by photosynthetic electron transport (in plants, the P450s are normally present in low abundance in the endoplasmic reticulum and they make only low amounts of terpenoids).

We have obtained proof of principle for this approach with one P450 system and the results were very impressive - terpenoid synthesis was driven at very high rates in chloroplastsusing electrons from the plant photsynthetic complexes.

The idea now is to try other, more commercially important terpenoids andI am writing to ask whether Abcam may be interested in collaborating in this project. In particular, we are applying for an ERANet collaborative grant application to work on these systems, and I wondered whether Abcam may be interested in being a named collaborator.

Of course I appreciate that you may need more scientific detail and these can be provided on request. For the moment, I can point you to one publication from the group here (with whom I collaborate): Jensen et al (2012). Trends in Plant Science vol 17, pages 1360-1363.

Otherwise, please get back to me if you are interested in pursuing these ideas.

Yours sincerely

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Answer

Thank you very much for your email.

I am having discussion with our Ascent scientific colleagues regarding the collaboration you have kindly offered. Could you clarify exactly what kind of collaboration you want from Abcam. Do you want to test product ab120190 etc.

I will look forward to hearing from you soon.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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