NLG919, small molecule IDO pathway inhibitor (ab231505)

Overview

  • Product name

    NLG919, small molecule IDO pathway inhibitor
  • Description

    Potent, small molecule IDO pathway inhibitor
  • Biological description

    NLG919 is a potent indoleamine 2,3-dioxygenase (IDO) pathway inhibitor (Ki = 7 nM; EC50 = 75 nM) in cell-free assays. It inhibits IDO-induced T cell suppression and restores T cell response during allogenic mixed lymphocyte reactions in vitro (ED50 = 80 and 120 nM, respectively). NLG919 promotes a 95% reduction in tumor volume in vivo when administered in conjunction with a pmel-1 T cell vaccine. NLG919 overcomes IDO-induced suppression of antigen-specific T-cells in in vitro models.

  • Purity

    100%
  • CAS Number

    1402836-58-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol

  • Molecular weight

    282.39
  • Molecular formula

    C18H22N2O
  • PubChem identifier

    66558287
  • Storage instructions

    Shipped at room temperature. Store at -20°C.
  • Solubility overview

    Ethanol = 106.23 mM (30 mg/ml)

    DMSO = 53.11 mM (15 mg/ml)(warmed)

     

  • SMILES

    C1CCC(CC1)C(CC2C3=CC=CC=C3C4=CN=CN24)O
  • Source

    Synthetic

References

This product has been referenced in:

  • Sun JJ  et al. Programmable co-delivery of the immune checkpoint inhibitor NLG919 and chemotherapeutic doxorubicin via a redox-responsive immunostimulatory polymeric prodrug carrier. Acta Pharmacol Sin 38:823-834 (2017). Read more (PubMed: 28504251) »
  • Zhai L  et al. Molecular Pathways: Targeting IDO1 and Other Tryptophan Dioxygenases for Cancer Immunotherapy. Clin Cancer Res 21:5427-33 (2015). Read more (PubMed: 26519060) »
  • Li M  et al. The indoleamine 2,3-dioxygenase pathway controls complement-dependent enhancement of chemo-radiation therapy against murine glioblastoma. J Immunother Cancer 2:21 (2014). Read more (PubMed: 25054064) »

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