Overview

  • Product name

  • Description

    Rabbit polyclonal to NLRC4
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human NLRC4 (C terminal) conjugated to keyhole limpet haemocyanin.

  • Positive control

    • Human Brain, Cortex tissue
  • General notes

     This product was previously labelled as CARD12

     

Properties

Applications

Our Abpromise guarantee covers the use of ab115537 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 2 µg/ml. Predicted molecular weight: 114 kDa.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use at an assay dependent concentration.

Target

  • Function

    Plays a role in the promotion of apoptosis.
  • Tissue specificity

    Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain.
  • Sequence similarities

    Contains 1 CARD domain.
    Contains 14 LRR (leucine-rich) repeats.
    Contains 1 NACHT domain.
  • Cellular localization

    Cytoplasm. Cytoplasmic filaments.
  • Information by UniProt
  • Database links

  • Alternative names

    • and NACHT-containing protein antibody
    • CARD 12 antibody
    • CARD antibody
    • CARD LRR and NACHT containing protein 1 antibody
    • CARD LRR and NACHT containing protein antibody
    • CARD12 antibody
    • Caspase recruitment domain containing protein 12 antibody
    • Caspase recruitment domain family member 12 antibody
    • Caspase recruitment domain-containing protein 12 antibody
    • CLAN 1 antibody
    • CLAN A antibody
    • CLAN antibody
    • CLAN B antibody
    • CLAN C antibody
    • CLAN D antibody
    • Clan protein antibody
    • CLAN1 antibody
    • CLANA antibody
    • CLANB antibody
    • CLANC antibody
    • CLAND antibody
    • CLR 2.1 antibody
    • CLR2.1 antibody
    • ICE protease activating factor antibody
    • Ice protease-activating factor antibody
    • Ipaf antibody
    • LRR antibody
    • NLR family CARD domain containing 4 antibody
    • NLR family CARD domain-containing protein 4 antibody
    • NLRC 4 antibody
    • NLRC4 antibody
    • NLRC4_HUMAN antibody
    • NOD like receptor C4 antibody
    • Nucleotide binding oligomerization domain leucine rich repeat and CARD domain containing 4 antibody
    • UNQ6189/PRO20215 antibody
    see all

Images

  • Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with ab115537 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

References

This product has been referenced in:

  • Nakamura H  et al. Altered expression of inflammasomes in Hirschsprung's disease. Pediatr Surg Int 35:15-20 (2019). Read more (PubMed: 30386901) »
  • Furman D  et al. Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states. Nat Med 23:174-184 (2017). Read more (PubMed: 28092664) »
See all 2 Publications for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab115537.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up