Key features and details
- Rabbit polyclonal to NLRP6
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-NLRP6 antibody
See all NLRP6 primary antibodies
DescriptionRabbit polyclonal to NLRP6
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Synthetic peptide corresponding to Human NLRP6 (internal sequence). (NP_612202).
Database link: P59044
- Human thyroid cancer and brain tissues.
This product was previously labelled as NALP6
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 49% PBS, 50% Glycerol (glycerin, glycerine)
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab198798 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/50 - 1/200.|
FunctionAs the sensor component of the NLRP6 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP6, PYCARD and CASP1 (and possibly CASP4 and CASP5). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. The precise NLRP6 activation stimulus has not been identified yet (By similarity) (PubMed:12387869). Essential for gut mucosal self-renewal and proliferation. Maintains intestinal homeostasis and a healthy intestinal microbiota. This function is, at least partially, mediated by IL18, and not IL1B, produced by nonhematopoietic cells. Influences intestinal barrier function and microbial homeostasis through the regulation of goblet cell mucus secretion. Acts by promoting autophagy in goblet cells, an essential step for mucus granule exocytosis. Its role in goblet cell physiology is inflammasome-dependent, but IL1B- and IL18-independent. During systemic bacterial infections, may negatively regulate inflammatory signaling and inhibit the influx of monocytes and neutrophils to the circulation and to the peritoneum. May promote peripheral nerve recovery following injury via an inflammasome-independent mechanism.
Tissue specificityExpressed in peripheral blood leukocytes, predominantly in granulocytes and, at lower levels, in CD4(+) and CD8(+) T-cells. Expressed in colonic myofibroblasts (at protein level) (PubMed:21593405).
Sequence similaritiesBelongs to the NLRP family.
Contains 5 LRR (leucine-rich) repeats.
Contains 1 NACHT domain.
Contains 1 pyrin domain.
Cellular localizationCytoplasm. Inflammasome. Cell membrane. Nucleus membrane.
- Information by UniProt
- Angiotensin II/vasopressin receptor antibody
- AVR antibody
- CLR11.4 antibody
ab198798 has been referenced in 1 publication.
- Zhu Y et al. Effects of NLRP6 on the proliferation and activation of human hepatic stellate cells. Exp Cell Res 370:383-388 (2018). PubMed: 29966662