Key features and details
- Rabbit polyclonal to NLRP6
- Reacts with: Recombinant fragment
- Isotype: IgG
Product nameAnti-NLRP6 antibody
See all NLRP6 primary antibodies
DescriptionRabbit polyclonal to NLRP6
Species reactivityReacts with: Recombinant fragment
Predicted to work with: Rat
Synthetic peptide corresponding to Human NLRP6 (C terminal).
This product was previously labelled as NALP6
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 7.2
Preservative: 0.01% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Concentration information loading...
PurityImmunogen affinity purified
Purification notesPurified by antigen specific affinity chromatography.
FunctionAs the sensor component of the NLRP6 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP6, PYCARD and CASP1 (and possibly CASP4 and CASP5). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. The precise NLRP6 activation stimulus has not been identified yet (By similarity) (PubMed:12387869). Essential for gut mucosal self-renewal and proliferation. Maintains intestinal homeostasis and a healthy intestinal microbiota. This function is, at least partially, mediated by IL18, and not IL1B, produced by nonhematopoietic cells. Influences intestinal barrier function and microbial homeostasis through the regulation of goblet cell mucus secretion. Acts by promoting autophagy in goblet cells, an essential step for mucus granule exocytosis. Its role in goblet cell physiology is inflammasome-dependent, but IL1B- and IL18-independent. During systemic bacterial infections, may negatively regulate inflammatory signaling and inhibit the influx of monocytes and neutrophils to the circulation and to the peritoneum. May promote peripheral nerve recovery following injury via an inflammasome-independent mechanism.
Tissue specificityExpressed in peripheral blood leukocytes, predominantly in granulocytes and, at lower levels, in CD4(+) and CD8(+) T-cells. Expressed in colonic myofibroblasts (at protein level) (PubMed:21593405).
Sequence similaritiesBelongs to the NLRP family.
Contains 5 LRR (leucine-rich) repeats.
Contains 1 NACHT domain.
Contains 1 pyrin domain.
Cellular localizationCytoplasm. Inflammasome. Cell membrane. Nucleus membrane.
- Information by UniProt
- Angiotensin II/vasopressin receptor antibody
- AVR antibody
- CLR11.4 antibody
ab58705 has been referenced in 2 publications.
- Lendermon EA et al. Azithromycin decreases NALP3 mRNA stability in monocytes to limit inflammasome-dependent inflammation. Respir Res 18:131 (2017). WB ; Human . PubMed: 28659178
- Sun Y et al. Stress-induced corticotropin-releasing hormone-mediated NLRP6 inflammasome inhibition and transmissible enteritis in mice. Gastroenterology 144:1478-87, 1487.e1-8 (2013). PubMed: 23470617