Key features and details
- Rabbit polyclonal to NLRP7
- Suitable for: IHC-P, ICC/IF, WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-NLRP7 antibody
See all NLRP7 primary antibodies
DescriptionRabbit polyclonal to NLRP7
SpecificityAt least four isoforms of NLRP7 are known to exist; this antibody will recognize all of them. This antibody is predicted to not cross-react with other NLRP family members.
Tested applicationsSuitable for: IHC-P, ICC/IF, WBmore details
Species reactivityReacts with: Human
Synthetic peptide corresponding to Human NLRP7 (N terminal).
Database link: Q8WX94
- Human brain tissue lysate, K562 cell lysate
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C.
Storage bufferpH: 7.2
Preservative: 0.02% Sodium azide
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab105405 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use a concentration of 10 µg/ml.|
|ICC/IF||Use a concentration of 20 µg/ml.|
|WB||Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 112 kDa.|
FunctionInhibits CASP1/caspase-1-dependent IL1B secretion.
Tissue specificityExpressed in numerous tissues including uterus and ovary, with low levels in heart and brain. Not detected in skeletal muscle.
Involvement in diseaseDefects in NLRP7 are the cause of hydatidiform mole (HYDM) [MIM:231090]. HYDM is an abnormal human pregnancy with no embryo and cystic degeneration of placental villi.
Sequence similaritiesBelongs to the NLRP family.
Contains 1 DAPIN domain.
Contains 9 LRR (leucine-rich) repeats.
Contains 1 NACHT domain.
- Information by UniProt
- CLR19.4 antibody
- FLJ94610 antibody
- HYDM antibody
All lanes : Anti-NLRP7 antibody (ab105405) at 2 µg/ml
Lane 1 : K562 cell lysate
Lane 2 : K562 cell lysate with Blocking peptide
Predicted band size: 112 kDa
Immunohistochemistry of Human brain tissue with ab105405 at 10 μg/mL.
Immunofluorescence of NLRP7 in Human brain tissue with ab105405 at 20 ug/mL.
ab105405 has been referenced in 1 publication.
- Bednash JS et al. Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity. Nat Commun 8:15203 (2017). WB, FM ; Human . PubMed: 28492230