Anti-NLRP7 antibody (ab126979)

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Overview

  • Product name

    Anti-NLRP7 antibody
    See all NLRP7 primary antibodies

  • Description

    Rabbit polyclonal to NLRP7

  • Host species

    Rabbit

  • Tested applications

    Suitable for: WBmore details

  • Species reactivity

    Reacts with: Human
    Predicted to work with: Monkey

  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 454-635 of Human NLRP7 (Q8WX94).

  • Positive control

    • 293T and Jurkat whole cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab126979 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 111 kDa.

Target

  • Function

    Inhibits CASP1/caspase-1-dependent IL1B secretion.

  • Tissue specificity

    Expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. Not detected in skeletal muscle.

  • Involvement in disease

    Defects in NLRP7 are the cause of hydatidiform mole (HYDM) [MIM:231090]. HYDM is an abnormal human pregnancy with no embryo and cystic degeneration of placental villi.

  • Sequence similarities

    Belongs to the NLRP family.
    Contains 1 DAPIN domain.
    Contains 9 LRR (leucine-rich) repeats.
    Contains 1 NACHT domain.
  • Information by UniProt

  • Database links

    • Alternative names

      • CLR19.4 antibody
      • FLJ94610 antibody
      • HYDM antibody
      • MGC126470 antibody
      • MGC126471 antibody
      • NACHT, leucine rich repeat and PYD containing 7 antibody
      • NACHT, LRR and PYD containing protein 7 antibody
      • NACHT, LRR and PYD domains containing protein 7 antibody
      • NACHT, LRR and PYD domains-containing protein 7 antibody
      • NALP7 antibody
      • NALP7_HUMAN antibody
      • NLR family, pyrin domain containing 7 antibody
      • NLRP7 antibody
      • NOD12 antibody
      • Nucleotide-binding oligomerization domain protein 12 antibody
      • Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 7 antibody
      • PAN7 antibody
      • PYPAF3 antibody
      • PYRIN-containing APAF1-like protein 3 antibody
      see all

    Images

    • Western blot - Anti-NLRP7 antibody (ab126979)
      Western blot - Anti-NLRP7 antibody (ab126979)
      Anti-NLRP7 antibody (ab126979) at 1/1000 dilution + Jurkat cell lysate at 30 µg

      Predicted band size: 111 kDa



      7.5% SDS PAGE

    References

    This product has been referenced in:

    • Lendermon EA  et al. Azithromycin decreases NALP3 mRNA stability in monocytes to limit inflammasome-dependent inflammation. Respir Res 18:131 (2017). WB ; Human . Read more (PubMed: 28659178) »
    See 1 Publication for this product

    Publishing research using ab126979? Please let us know so that we can cite the reference in this datasheet.

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