Anti-NLRP7 antibody (ab126979)
Key features and details
- Rabbit polyclonal to NLRP7
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-NLRP7 antibody
See all NLRP7 primary antibodies -
Description
Rabbit polyclonal to NLRP7 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Monkey
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Immunogen
Recombinant fragment, corresponding to a region within amino acids 454-635 of Human NLRP7 (Q8WX94).
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Positive control
- 293T and Jurkat whole cell lysates.
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General notes
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol (glycerin, glycerine) -
Concentration information loading... -
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
Applications
Our Abpromise guarantee covers the use of ab126979 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB | 1/500 - 1/3000. Predicted molecular weight: 111 kDa. |
Target
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Function
Inhibits CASP1/caspase-1-dependent IL1B secretion. -
Tissue specificity
Expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. Not detected in skeletal muscle. -
Involvement in disease
Defects in NLRP7 are the cause of hydatidiform mole (HYDM) [MIM:231090]. HYDM is an abnormal human pregnancy with no embryo and cystic degeneration of placental villi. -
Sequence similarities
Belongs to the NLRP family.
Contains 1 DAPIN domain.
Contains 9 LRR (leucine-rich) repeats.
Contains 1 NACHT domain. - Information by UniProt
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Database links
- Entrez Gene: 199713 Human
- Omim: 609661 Human
- SwissProt: Q8WX94 Human
- Unigene: 351118 Human
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Alternative names
- CLR19.4 antibody
- FLJ94610 antibody
- HYDM antibody
see all
Images
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Western blot - Anti-NLRP7 antibody (ab126979)Anti-NLRP7 antibody (ab126979) at 1/1000 dilution + Jurkat cell lysate at 30 µg
Predicted band size: 111 kDa
7.5% SDS PAGE
References (2)
ab126979 has been referenced in 2 publications.
- Zhang P et al. Abnormal processing of IL-1ß in NLRP7-mutated monocytes in hydatidiform mole patients. Clin Exp Immunol N/A:N/A (2020). PubMed: 32484253
- Lendermon EA et al. Azithromycin decreases NALP3 mRNA stability in monocytes to limit inflammasome-dependent inflammation. Respir Res 18:131 (2017). WB ; Human . PubMed: 28659178
