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    nlrx1-antibody-ab105412.pdf

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Immunology Innate Immunity Macrophage / Inflamm.
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Anti-NLRX1 antibody (ab105412)

  • Datasheet
  • SDS
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Immunocytochemistry/ Immunofluorescence - Anti-NLRX1 antibody (ab105412)
  • Western blot - Anti-NLRX1 antibody (ab105412)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NLRX1 antibody (ab105412)

Key features and details

  • Rabbit polyclonal to NLRX1
  • Suitable for: ICC/IF, WB, IHC-P
  • Reacts with: Rat
  • Isotype: IgG

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Overview

  • Product name

    Anti-NLRX1 antibody
    See all NLRX1 primary antibodies
  • Description

    Rabbit polyclonal to NLRX1
  • Host species

    Rabbit
  • Specificity

    At least two isoforms of NLRX1 are known to exist; ab105412 will recognize both. This antibody is predicted to not crossreact with other NLRP family members.
  • Tested Applications & Species

    Application Species
    ICC/IF
    Rat
    IHC-P
    Rat
    WB
    Rat
    See all applications and species data
  • Immunogen

    A 14 amino acid peptide near the amino terminus of Human NLRX1 (NP_078894).

  • Positive control

    • Rat spleen tissue lysate

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C.
  • Storage buffer

    pH: 7.2
    Preservative: 0.02% Sodium azide
    Constituent: PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Immunology
    • Innate Immunity
    • Macrophage / Inflamm.

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab105412 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Guaranteed

Tested applications are guaranteed to work and covered by our Abpromise guarantee.

Predicted

Predicted to work for this combination of applications and species but not guaranteed.

Incompatible

Does not work for this combination of applications and species.

Application Species
ICC/IF
Rat
IHC-P
Rat
WB
Rat
Application Abreviews Notes
ICC/IF
Use a concentration of 20 µg/ml.
WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 108 kDa.
IHC-P
Use a concentration of 10 µg/ml.
Notes
ICC/IF
Use a concentration of 20 µg/ml.
WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 108 kDa.
IHC-P
Use a concentration of 10 µg/ml.

Target

  • Function

    Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Has no inhibitory function on NF-Kappa-B and type 1 interferon signaling pathways, but enhances NF-Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313).
  • Tissue specificity

    Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HELA, 293T, THP-1, HL60, RAJI, and JURKAT cell lines (at protein level).
  • Sequence similarities

    Belongs to the NLRP family.
    Contains 7 LRR (leucine-rich) repeats.
    Contains 1 NACHT domain.
  • Cellular localization

    Mitochondrion outer membrane.
  • Target information above from: UniProt accession Q86UT6 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 315599 Rat
    • SwissProt: Q5FVQ8 Rat
    • Unigene: 12444 Rat
    • Alternative names

      • Caterpiller protein 11.3 antibody
      • CLR11.3 antibody
      • DLNB26 antibody
      • FLJ21478 antibody
      • MGC131937 antibody
      • MGC21025 antibody
      • NLR family member X1 antibody
      • NLR family, X1 antibody
      • Nlrx1 antibody
      • NLRX1_HUMAN antibody
      • NOD-like receptor X1 antibody
      • NOD26 antibody
      • NOD5 antibody
      • NOD9 antibody
      • Nucleotide-binding oligomerization domain protein 26 antibody
      • Nucleotide-binding oligomerization domain protein 5 antibody
      • Nucleotide-binding oligomerization domain protein 9 antibody
      • nucleotide-binding oligomerization domain, leucine rich repeat containing X1 antibody
      • Protein Caterpiller 11.3 antibody
      see all

    Images

    • Immunocytochemistry/ Immunofluorescence - Anti-NLRX1 antibody (ab105412)
      Immunocytochemistry/ Immunofluorescence - Anti-NLRX1 antibody (ab105412)

      Immunofluorescence of NLRX1 in rat spleen tissue with ab105412 at 20 ug/mL.

    • Western blot - Anti-NLRX1 antibody (ab105412)
      Western blot - Anti-NLRX1 antibody (ab105412)
      Lane 1 : Anti-NLRX1 antibody (ab105412) at 1 µg/ml
      Lane 2 : Anti-NLRX1 antibody (ab105412) at 2 µg/ml

      All lanes : rat spleen tissue cell lysate

      Predicted band size: 108 kDa

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NLRX1 antibody (ab105412)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NLRX1 antibody (ab105412)
      Immunohistochemistry of NLRX1 in rat spleen tissue with ab105412 at 10 µg/ml.

    Protocols

    • Western blot protocols
    • Immunocytochemistry & immunofluorescence protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
    • SDS
  • References (1)

    Publishing research using ab105412? Please let us know so that we can cite the reference in this datasheet.

    ab105412 has been referenced in 1 publication.

    • Peng L  et al. DJ-1 exerts anti-inflammatory effects and regulates NLRX1-TRAF6 via SHP-1 in stroke. J Neuroinflammation 17:81 (2020). PubMed: 32151250

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