- Datasheet
- Specific References
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Overview
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Product nameAnti-NLRX1 antibody
See all NLRX1 primary antibodies -
DescriptionRabbit polyclonal to NLRX1
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Host speciesRabbit
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SpecificityAt least two isoforms of NLRX1 are known to exist; ab105412 will recognize both. This antibody is predicted to not crossreact with other NLRP family members.
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Tested applicationsSuitable for: ICC/IF, WB, ICCmore details
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Species reactivityReacts with: Mouse, Rat, Human
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Immunogen
A 14 amino acid peptide near the amino terminus of Human NLRX1 (NP_078894).
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Positive control
- Rat spleen tissue lysate
Properties
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FormLiquid
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Storage instructionsShipped at 4°C. Store at +4°C.
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Storage bufferPreservative: 0.02% Sodium Azide
Constituents: PBS -
Concentration information loading... -
PurityImmunogen affinity purified
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ClonalityPolyclonal
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IsotypeIgG
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Research areas
Associated products
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Compatible Secondaries
Applications
Our Abpromise guarantee covers the use of ab105412 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| ICC/IF | Use a concentration of 20 µg/ml. | |
| WB | Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 108 kDa. | |
| ICC | Use a concentration of 10 µg/ml. |
Target
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FunctionParticipates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Has no inhibitory function on NF-Kappa-B and type 1 interferon signaling pathways, but enhances NF-Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313).
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Tissue specificityUbiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HELA, 293T, THP-1, HL60, RAJI, and JURKAT cell lines (at protein level).
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Sequence similaritiesBelongs to the NLRP family.
Contains 7 LRR (leucine-rich) repeats.
Contains 1 NACHT domain. -
Cellular localizationMitochondrion outer membrane.
- Information by UniProt
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Database links
- Entrez Gene: 79671 Human
- Entrez Gene: 270151 Mouse
- Entrez Gene: 315599 Rat
- Omim: 611947 Human
- SwissProt: Q86UT6 Human
- SwissProt: Q3TL44 Mouse
- SwissProt: Q5FVQ8 Rat
- Unigene: 524082 Human
see all -
Alternative names
- Caterpiller protein 11.3 antibody
- CLR11.3 antibody
- DLNB26 antibody
see all
Images
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Immunocytochemistry/ Immunofluorescence - Anti-NLRX1 antibody (ab105412)Immunofluorescence of NLRX1 in rat spleen tissue with ab105412 at 20 ug/mL.
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Western blot - Anti-NLRX1 antibody (ab105412)Lane 1 : Anti-NLRX1 antibody (ab105412) at 1 µg/ml
Lane 2 : Anti-NLRX1 antibody (ab105412) at 2 µg/ml
All lanes : rat spleen tissue cell lysate
Predicted band size: 108 kDa -
Immunocytochemistry/ Immunofluorescence - Anti-NLRX1 antibody (ab105412)Immunohistochemistry of NLRX1 in rat spleen tissue with ab105412 at 10 µg/ml.
References
ab105412 has not yet been referenced specifically in any publications.
Customer reviews and Q&As
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"