N,N-Dimethyl-D-erythro-sphingosine (PKC inhibitor), Sphingosine kinase and PKC inhibitor (ab141237)

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Overview

  • Product name

    N,N-Dimethyl-D-erythro-sphingosine (PKC inhibitor), Sphingosine kinase and PKC inhibitor

  • Description

    Sphingosine kinase and PKC inhibitor

  • Biological description

    Inhibitor of sphingosine kinase (IC50=5 µM) and PKC (IC50=12 µM). Blocks conversion of sphingosine to sphingosine-1-phosphate. Induces apoptosis and EGFR autophosphorylation. Produced via ceramide catabolism. Active in vitro.

  • Purity

    > 98%

  • CAS Number

    119567-63-4

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (E,2S,3R)-2-(Dimethylamino)octadec-4-ene-1,3-diol

  • Molecular weight

    327.55

  • Molecular formula

    C20H41NO2

  • PubChem identifier

    5282309

  • Storage instructions

    Store at -20°C (desiccating conditions).

  • Solubility overview

    Supplied in isopropanol (5 mg/ml)

  • Handling

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCCCCCCCCCCCC/C=C/[C@H]([C@H](CO)N(C)C)O

  • Source

    Synthetic

References

This product has been referenced in:

  • Kim HL & Im DS N, N-dimethyl-D-erythro-sphingosine increases intracellular Ca2+ concentration via Na+-Ca2+-exchanger in HCT116 human colon cancer cells. Arch Pharm Res 31:54-9 (2008). Read more (PubMed: 18277608) »
  • Yatomi Y  et al. N,N-dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets. Biochemistry 35:626-33 (1996). Read more (PubMed: 8555236) »
  • Khan WA  et al. Use of D-erythro-sphingosine as a pharmacological inhibitor of protein kinase C in human platelets. Biochem J 278 ( Pt 2):387-92 (1991). Read more (PubMed: 1898331) »

Publishing research using ab141237? Please let us know so that we can cite the reference in this datasheet.

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