Product nameN,N'-Ethylenebis(iodoacetamide), Tubulin conformational state probe
DescriptionTubulin conformational state probe.
- Ethylenediamine bis(iodoacetamide)
Homobifunctional sulfhydryl-reactive crosslinker. Used as a probe for the conformational state of free tubulin molecules. Reacts specifically with the sulfhydryl groups.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Luduena RF & Roach MC Tubulin sulfhydryl groups as probes and targets for antimitotic and antimicrotubule agents. Pharmacol Ther 49:133-52 (1991). Read more (PubMed: 1852786) »
- Ludueña RF & Roach MC Interaction of tubulin with drugs and alkylating agents. 1. Alkylation of tubulin by iodo[14C]acetamide and N,N'-ethylenebis(iodoacetamide). Biochemistry 20:4437-44 (1981). Read more (PubMed: 7284333) »