Overview

  • Product name

    NNC 711, GAT-1 inhibitor
  • Description

    Potent, selective GAT-1 inhibitor
  • Biological description

    Potent and selective GAT-1 GABA uptake inhibitor. (IC50 values are 0.04 (hGAT-1), 171 (rGAT-2), 1700 (hGAT-3) and 622 μM (hBGT-1)). Selective over a range of other neurotransmitter receptor binding sites, uptake sites and ion channels in vitro. Potent anticonvulsant, neuroprotectant and cognitive enhancer in vivo.

    Also available in simple stock solutions (ab146719) - add 1 ml of water to get an exact, ready-to-use concentration.
  • Purity

    > 99%
  • CAS Number

    145645-62-1
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • O'Connell AW  et al. Anti-ischemic and cognition-enhancing properties of NNC-711, a gamma-aminobutyric acid reuptake inhibitor. Eur J Pharmacol 424:37-44 (2001). Read more (PubMed: 11470258) »
  • Borden LA  et al. Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur J Pharmacol 269:219-24 (1994). Read more (PubMed: 7851497) »
  • Suzdak PD  et al. NNC-711, a novel potent and selective gamma-aminobutyric acid uptake inhibitor: pharmacological characterization. Eur J Pharmacol 224:189-98 (1992). Read more (PubMed: 1468507) »
See 1 Publication for this product

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