Overview

  • Product name

  • Description

    Rabbit polyclonal to NNT1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Recombinant fragment corresponding to Human NNT1 aa 28-178.
    Database link: Q9UBD9

  • Positive control

    • IHC-P: Human kidney tissue.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.4
    Preservative: 0.03% Proclin
    Constituents: 50% Glycerol, PBS
  • Concentration information loading...
  • Purity

    Protein G purified
  • Purification notes

    Purity greater than 95%.
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab238853 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/200 - 1/500.

Target

  • Function

    Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor.
  • Tissue specificity

    Expressed predominantly in lymph nodes, spleen, peripheral blood lymphocytes, bone marrow, and fetal liver.
  • Involvement in disease

    Defects in CLCF1 are the cause of cold-induced sweating syndrome type 2 (CISS2) [MIM:610313]. Cold-induced sweating syndrome (CISS) is an autosomal recessive disorder characterized by profuse sweating induced by cool surroundings (temperatures of 7 to 18 degrees Celsius). Additional abnormalities include a high-arched palate, nasal voice, depressed nasal bridge, inability to fully extend the elbows and kyphoscoliosis.
  • Sequence similarities

    Belongs to the IL-6 superfamily.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • B cell stimulating factor 3 antibody
    • B-cell-stimulating factor 3 antibody
    • BSF 3 antibody
    • BSF-3 antibody
    • BSF3 antibody
    • Cardiotrophin like cytokine antibody
    • Cardiotrophin like cytokine factor 1 antibody
    • Cardiotrophin-like cytokine factor 1 antibody
    • CISS 2 antibody
    • CISS2 antibody
    • CLC antibody
    • CLCF 1 antibody
    • Clcf1 antibody
    • CLCF1_HUMAN antibody
    • Cold induced sweating syndrome 2 antibody
    • CRLF 1 associated cytokine like factor 1 antibody
    • CRLF1 associated cytokine like factor 1 antibody
    • Neurotrophin 1 antibody
    • Neurotrophin 1/B cell stimulating factor 3 antibody
    • Neurotrophin1 antibody
    • NNT 1 antibody
    • NNT-1 antibody
    • Novel neurotrophin 1 antibody
    • Novel neurotrophin-1 antibody
    • NR 6 antibody
    • NR6 antibody
    see all

Images

  • Paraffin-embedded human kidney tissue stained for NNT1 using ab238853 at 1/200 dilution in immunohistochemical analysis.

    After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30 minutes at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system

References

ab238853 has not yet been referenced specifically in any publications.

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