Nobiletin, Matrix metalloprotease (MMP) inhibitor (ab142927)

Overview

  • Product name

    Nobiletin, Matrix metalloprotease (MMP) inhibitor
  • Description

    Polymethoxylated flavone. Potent MMP inhibitor.
  • Biological description

    Polymethoxylated flavone. Potent MMP inhibitor. Inhibits proMMP-1, 3, and 9 production. Shows anti-inflammatory and antitumor effects in vivo. Orally active.
  • Purity

    > 97%
  • CAS Number

    478-01-3
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Yang EJ  et al. Identification of active compounds from Aurantii Immatri Pericarpium attenuating brain injury in a rat model of ischemia-reperfusion. Food Chem 138:663-70 (2013). Read more (PubMed: 23265538) »
  • Nemoto K  et al. Characteristics of nobiletin-mediated alteration of gene expression in cultured cell lines. Biochem Biophys Res Commun 431:530-4 (2013). Read more (PubMed: 23321314) »
  • Sasaki K  et al. Effect of flavones on rat brain and lung matrix metalloproteinase activity measured by film in-situ zymography. J Pharm Pharmacol 57:459-65 (2005). Read more (PubMed: 15831206) »
  • Minagawa A  et al. The citrus flavonoid, nobiletin, inhibits peritoneal dissemination of human gastric carcinoma in SCID mice. Jpn J Cancer Res 92:1322-8 (2001). Read more (PubMed: 11749698) »

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