Key features and details
- Rabbit polyclonal to NOC2L
- Suitable for: IHC-P, WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-NOC2L antibody
DescriptionRabbit polyclonal to NOC2L
SpecificityThis antibody detects endogenous levels of total NOC2L protein.
Tested applicationsSuitable for: IHC-P, WBmore details
Species reactivityReacts with: Human
Fusion protein corresponding to Human NOC2L (internal sequence). The identity of the protein fusion partner is GST.
Database link: Q9Y3T9
- Human prostate cancer tissue, HeLa cell lysate.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 49% PBS, 50% Glycerol (glycerin, glycerine)
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab198171 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/25 - 1/100.|
|WB||1/200 - 1/1000. Predicted molecular weight: 85 kDa.|
FunctionActs as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter.
Sequence similaritiesBelongs to the NOC2 family.
Cellular localizationNucleus > nucleoplasm. Nucleus > nucleolus. Translocates from the nucleoli to the nucleoplasm in presence of several stressors like ultraviolet irradiation and actinomycin-D. Predominantly detected in the nucleoli in non-mitotic cells. Predominantly detected in nucleoplasma in cells undergoing mitosis.
- Information by UniProt
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Immunohistochemical analysis of paraffin-embedded human prostate cancer tissue labeling NOC2L with ab198171 at a 1/20 dilution.
Anti-NOC2L antibody (ab198171) at 1/200 dilution + HeLa cell lysate at 40 µg
Developed using the ECL technique.
Predicted band size: 85 kDa
Exposure time: 5 seconds
ab198171 has not yet been referenced specifically in any publications.