Overview

  • Product name

    Anti-NOC2L antibody
  • Description

    Rabbit polyclonal to NOC2L
  • Host species

    Rabbit
  • Specificity

    This antibody detects endogenous levels of total NOC2L protein.
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Fusion protein corresponding to Human NOC2L (internal sequence). The identity of the protein fusion partner is GST.
    Database link: Q9Y3T9

  • Positive control

    • Human prostate cancer tissue, HeLa cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab198171 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/25 - 1/100.
WB 1/200 - 1/1000. Predicted molecular weight: 85 kDa.

Target

  • Function

    Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter.
  • Sequence similarities

    Belongs to the NOC2 family.
  • Cellular localization

    Nucleus > nucleoplasm. Nucleus > nucleolus. Translocates from the nucleoli to the nucleoplasm in presence of several stressors like ultraviolet irradiation and actinomycin-D. Predominantly detected in the nucleoli in non-mitotic cells. Predominantly detected in nucleoplasma in cells undergoing mitosis.
  • Information by UniProt
  • Database links

  • Alternative names

    • NET15 antibody
    • NET7 antibody
    • NIR antibody
    • NOC2 like antibody
    • NOC2 like nucleolar associated transcriptional repressor antibody
    • NOC2-like protein antibody
    • NOC2L antibody
    • NOC2L nucleolar associated transcriptional repressor antibody
    • NOC2L_HUMAN antibody
    • Novel INHAT (inhibitor of histone acetyltransferase) repressor antibody
    • Novel INHAT repressor antibody
    • Nucleolar complex associated 2 homolog (S. cerevisiae) antibody
    • Nucleolar complex protein 2 homolog antibody
    • PPP1R112 antibody
    • Protein NOC2 homolog antibody
    • Protein phosphatase 1 regulatory subunit 12 antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded human prostate cancer tissue labeling NOC2L with ab198171 at a 1/20 dilution.

  • Anti-NOC2L antibody (ab198171) at 1/200 dilution + HeLa cell lysate at 40 µg

    Developed using the ECL technique.

    Predicted band size: 85 kDa


    Exposure time: 5 seconds


    Gel: 6%SDS-PAGE

References

ab198171 has not yet been referenced specifically in any publications.

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