Overview

  • Product name

  • Description

    Rabbit polyclonal to Nociceptin
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Rat
    Predicted to work with: Mouse, Cow, Human, Pig
  • Immunogen

    Synthetic peptide corresponding to Human Nociceptin aa 130-142 conjugated to keyhole limpet haemocyanin.
    Sequence:

    FGGFTGARKSARK


    Database link: Q13519

  • Positive control

    • Rat brain tissue. Rat brain lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab216413 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500.
WB 1/100 - 1/1000. Detects a band of approximately 19 kDa (predicted molecular weight: 20 kDa).

Target

  • Function

    Nociceptin: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development.
    Nocistatin: Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia.
    Orphanin FQ2: Has potent analgesic activity.
  • Tissue specificity

    Predominantly expressed in the brain and spinal cord. Also expressed and secreted by peripheral blood neutrophils following degranulation.
  • Sequence similarities

    Belongs to the opioid neuropeptide precursor family.
  • Post-translational
    modifications

    Specific enzymatic cleavages at paired basic residues probably yield other active peptides besides nociceptin.
    The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • N/OFQ antibody
    • N23K antibody
    • N23K/N27K antibody
    • Nociceptin, included antibody
    • nocistatin antibody
    • Npnc1 antibody
    • OFQ antibody
    • OFQ/N antibody
    • Orphanin FQ antibody
    • Orphanin FQ2 antibody
    • Pnoc antibody
    • PNOC_HUMAN antibody
    • ppN/OFQ antibody
    • PPNOC antibody
    • pre-pro-N/OFQ antibody
    • prepronociceptin antibody
    • pronociceptin antibody
    • Propronociceptin antibody
    see all

Images

  • All lanes : Anti-Nociceptin antibody (ab216413) at 1/200 dilution

    Lane 1 : rat brain lysate
    Lane 2 : rat liver lysate

    Secondary
    All lanes : Goat Anti-Rabbit IgG Antibody (H+L), HRP at 1/3000 dilution

    Developed using the ECL technique.

    Predicted band size: 20 kDa



    15% gel.

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded rat brain tissue labeling Nociceptin with ab216413 at 1/300 dilution, followed by conjugation to the secondary antibody and DAB staining.

References

ab216413 has not yet been referenced specifically in any publications.

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