Overview

  • Product name

    Nomilin, Phase II detoxifying enzymes inducer
  • Description

    Phase II detoxifying enzymes inducer
  • Biological description

    Antiangiogenic and chemopreventive effects. Shows antitumor and immunomodulatory effects in vivo. Reduces serum VEGF. Orally active.
  • Purity

    > 98%
  • CAS Number

    1063-77-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-(Acetyloxy)-1,2-dihydroobacunoic acid ε-lactone
  • Molecular weight

    514.56
  • Molecular formula

    C28H34O9
  • PubChem identifier

    72320
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(=O)OC1CC(=O)OC(C2C1(C3CCC4(C(OC(=O)C5C4(C3(C(=O)C2)C)O5)C6=COC=C6)C)C)(C)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Ono E  et al. Anti-obesity and anti-hyperglycemic effects of the dietary citrus limonoid nomilin in mice fed a high-fat diet. Biochem Biophys Res Commun 410:677-81 (2011). Read more (PubMed: 21693102) »
  • Pratheeshkumar P & Kuttan G Nomilin inhibits tumor-specific angiogenesis by downregulating VEGF, NO and proinflammatory cytokine profile and also by inhibiting the activation of MMP-2 and MMP-9. Eur J Pharmacol 668:450-8 (2011). Read more (PubMed: 21839074) »
  • Kuttan G  et al. Inhibition of tumor progression by naturally occurring terpenoids. Pharm Biol 49:995-1007 (2011). Read more (PubMed: 21936626) »

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