Overview

  • Product name

    Nonivamide, TRPV1 agonist
  • Description

    TRPV1 agonist. Capsaicin analog.
  • Biological description

    TRPV1 agonist. Less potent Capsaicin (ab141000) analog. Induces Ca2+ release from ER. Blood-brain barrier permeable. Active in vivo.
  • Purity

    > 98%
  • CAS Number

    2444-46-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-(4-Hydroxy-3-methoxybenzyl)nonanamide
  • Molecular weight

    293.41
  • Molecular formula

    C17H27NO3
  • PubChem identifier

    2998
  • Storage instructions

    Store at +4°C.
  • Solubility overview

    Soluble in ethanol to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Oc1ccc(cc1OC)CNC(=O)CCCCCCCC
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Thomas KC  et al. Contributions of TRPV1, endovanilloids, and endoplasmic reticulum stress in lung cell death in vitro and lung injury. Am J Physiol Lung Cell Mol Physiol 302:L111-9 (2012). Read more (PubMed: 21949157) »
  • Thomas KC  et al. Transient receptor potential vanilloid 1 agonists cause endoplasmic reticulum stress and cell death in human lung cells. J Pharmacol Exp Ther 321:830-8 (2007). Read more (PubMed: 17332266) »
  • Skofitsch G  et al. Comparison of nonivamide and capsaicin with regard to their pharmacokinetics and effects on sensory neurons. Arzneimittelforschung 34:154-6 (1984). Read more (PubMed: 6202305) »

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