Anti-NOR1/TEC antibody (ab155535)
Key features and details
- Rabbit polyclonal to NOR1/TEC
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-NOR1/TEC antibody
See all NOR1/TEC primary antibodies -
Description
Rabbit polyclonal to NOR1/TEC -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
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Positive control
- NT2D1, U87-MG, IMR32 and MCF7 whole cell lysate
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab155535 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/3000. Predicted molecular weight: 70 kDa.
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Notes |
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WB
1/500 - 1/3000. Predicted molecular weight: 70 kDa. |
Target
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Function
Binds to the B1A response-element. -
Tissue specificity
Isoform alpha is highly expressed in skeletal muscle. Isoform beta is highly expressed in skeletal muscle and low expressed in fetal brain and placenta. -
Involvement in disease
Defects in NR4A3 are a cause of Ewing sarcoma (ES) [MIM:612219]. A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. Note=A chromosomal aberration involving NR4A3 is found in patients with Erwing sarcoma. Translocation t(9;22)(q22-31;q11-12) with EWSR1.
Note=A chromosomal aberration involving NR4A3 is a cause of a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with TAF2N. -
Sequence similarities
Belongs to the nuclear hormone receptor family. NR4 subfamily.
Contains 1 nuclear receptor DNA-binding domain. -
Cellular localization
Nucleus. - Information by UniProt
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Database links
- Entrez Gene: 8013 Human
- Omim: 600542 Human
- SwissProt: Q92570 Human
- Unigene: 279522 Human
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Alternative names
- CHN antibody
- Chondrosarcoma, extraskeletal myxoid, fused to EWS antibody
- CSMF antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (3)
ab155535 has been referenced in 3 publications.
- Wang H et al. Long non-coding RNA LINC00467 drives hepatocellular carcinoma progression via inhibiting NR4A3. J Cell Mol Med 24:3822-3836 (2020). PubMed: 32125766
- Van Ngo H et al. A role for host cell exocytosis in InlB-mediated internalisation of Listeria monocytogenes. Cell Microbiol 19:N/A (2017). PubMed: 28745416
- Xiang T et al. Oxidored-nitro domain-containing protein 1 promotes liver fibrosis by activating the Wnt/ß-catenin signaling pathway in vitro. Mol Med Rep 16:5050-5054 (2017). PubMed: 28791396