Anti-NOR1/TEC antibody - C-terminal (ab188752)
Key features and details
- Rabbit polyclonal to NOR1/TEC - C-terminal
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
-
Product name
Anti-NOR1/TEC antibody - C-terminal
See all NOR1/TEC primary antibodies -
Description
Rabbit polyclonal to NOR1/TEC - C-terminal -
Host species
Rabbit -
Specificity
BLAST analysis of the peptide immunogen showed no homology with other Human proteins. -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Rabbit, Hamster, Cow, Dog, Pig, Monkey, Gorilla -
Immunogen
Synthetic peptide corresponding to Human NOR1/TEC (C terminal). The peptide corresponds to 20 amino acids (NP_008912.2)
Database link: Q92570 -
Positive control
- Human brain, neurons and glia.
-
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.4
Preservative: 0.1% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
-
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab188752 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
IHC-P |
Use a concentration of 10 - 20 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
|
Notes |
---|
IHC-P
Use a concentration of 10 - 20 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. |
Target
-
Function
Binds to the B1A response-element. -
Tissue specificity
Isoform alpha is highly expressed in skeletal muscle. Isoform beta is highly expressed in skeletal muscle and low expressed in fetal brain and placenta. -
Involvement in disease
Defects in NR4A3 are a cause of Ewing sarcoma (ES) [MIM:612219]. A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. Note=A chromosomal aberration involving NR4A3 is found in patients with Erwing sarcoma. Translocation t(9;22)(q22-31;q11-12) with EWSR1.
Note=A chromosomal aberration involving NR4A3 is a cause of a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with TAF2N. -
Sequence similarities
Belongs to the nuclear hormone receptor family. NR4 subfamily.
Contains 1 nuclear receptor DNA-binding domain. -
Cellular localization
Nucleus. - Information by UniProt
-
Database links
- Entrez Gene: 528877 Cow
- Entrez Gene: 100684628 Dog
- Entrez Gene: 8013 Human
- Entrez Gene: 717560 Monkey
- Entrez Gene: 18124 Mouse
- Entrez Gene: 397479 Pig
- Entrez Gene: 58853 Rat
- Omim: 600542 Human
see all -
Alternative names
- CHN antibody
- Chondrosarcoma, extraskeletal myxoid, fused to EWS antibody
- CSMF antibody
see all
Images
-
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain, neurons and glia labeling NOR1/TEC with ab188752 at 7 µg/ml.
-
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human skin melanoma tissue labelling NOR1/TEC with ab188752. Heat-induced antigen retrieval was performed.
Datasheets and documents
-
SDS download
-
Datasheet download
References (0)
ab188752 has not yet been referenced specifically in any publications.