Overview

  • Product name

    Anti-NOR1/TEC antibody - C-terminal
    See all NOR1/TEC primary antibodies
  • Description

    Rabbit polyclonal to NOR1/TEC - C-terminal
  • Host species

    Rabbit
  • Specificity

    BLAST analysis of the peptide immunogen showed no homology with other Human proteins.
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Hamster, Cow, Dog, Pig, Monkey, Gorilla
  • Immunogen

    Synthetic peptide corresponding to Human NOR1/TEC (C terminal). The peptide corresponds to 20 amino acids (NP_008912.2)
    Database link: Q92570

  • Positive control

    • Human brain, neurons and glia.
  • General notes

     This product was previously labelled as NOR1

     

Properties

Applications

Our Abpromise guarantee covers the use of ab188752 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 10 - 20 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function

    Binds to the B1A response-element.
  • Tissue specificity

    Isoform alpha is highly expressed in skeletal muscle. Isoform beta is highly expressed in skeletal muscle and low expressed in fetal brain and placenta.
  • Involvement in disease

    Defects in NR4A3 are a cause of Ewing sarcoma (ES) [MIM:612219]. A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. Note=A chromosomal aberration involving NR4A3 is found in patients with Erwing sarcoma. Translocation t(9;22)(q22-31;q11-12) with EWSR1.
    Note=A chromosomal aberration involving NR4A3 is a cause of a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with TAF2N.
  • Sequence similarities

    Belongs to the nuclear hormone receptor family. NR4 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • CHN antibody
    • Chondrosarcoma, extraskeletal myxoid, fused to EWS antibody
    • CSMF antibody
    • MINOR antibody
    • Mitogen induced nuclear orphan receptor antibody
    • Mitogen-induced nuclear orphan receptor antibody
    • Neuron derived orphan receptor 1 antibody
    • Neuron derived orphan receptor antibody
    • Neuron-derived orphan receptor 1 antibody
    • NOR1 antibody
    • Nr4a3 antibody
    • NR4A3_HUMAN antibody
    • Nuclear hormone receptor NOR-1 antibody
    • Nuclear hormone receptor NOR1 antibody
    • Nuclear receptor subfamily 4 group A member 3 antibody
    • TEC antibody
    • Translocated in extraskeletal chondrosarcoma antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain, neurons and glia labeling NOR1/TEC with ab188752 at 7 µg/ml.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human skin melanoma tissue labelling NOR1/TEC with ab188752. Heat-induced antigen retrieval was performed.

References

ab188752 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab188752.
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