Key features and details
- Mouse monoclonal [NVGC-01] to Norovirus Capsid protein VP1
- Suitable for: WB
- Reacts with: Recombinant fragment
- Isotype: IgG1
Product nameAnti-Norovirus Capsid protein VP1 antibody [NVGC-01]
See all Norovirus Capsid protein VP1 primary antibodies
DescriptionMouse monoclonal [NVGC-01] to Norovirus Capsid protein VP1
Reacts with Norovirus capsid proteins of both genogroup I and genogroup II.
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Recombinant fragment
- WB: Recombinant norovirus capsid protein of Genogroup I (Norwalk virus) and Genogroup II (Snow mountain virus)
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle.
Storage bufferpH: 6.5
Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Concentration information loading...
PurityProtein A purified
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab272687 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/1000.
1/500 - 1/1000.
RelevanceNorovirus is an RNA virus of the Caliciviridae taxonomic family, causes approximately 90% of epidemic non bacterial outbreaks of gastroenteritis around the world and is responsible for 50% of all foodborne outbreaks of gastroenteritis in the US. Norovirus affects people of all ages. The viruses are transmitted by faecally contaminated food or water and by person to person contact. Noroviruses contain a positive-sense RNA genome of approximately 7.5 kbp, encoding a major structural protein (VP1) of about 58~60 kDa and a minor capsid protein (VP2). The virus particles demonstrate an amorphous surface structure when visualized using electron microscopy and are between 27-38 nm in size. Capsid protein VP1 attaches virion to target cells by binding histo-blood group antigens present on gastroduodenal epithelial cells. Soluble capsid protein may play a role in viral immunoevasion. Capsid protein VP1 binds to histoblood group antigens at surface of target cells. The shell domain (S domain) contains elements essential for the formation of the icosahedron. The Protruding domain (P domain) is divided into subdomains P1 and P2. P domain interacts in dimeric contacts that increase the stability of the capsid and form the protrusions on the virion. An hypervariable region in P2 is thought to play an important role in receptor binding and immune reactivity.
- VP1 antibody
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab272687 has not yet been referenced specifically in any publications.