Overview

  • Product name

    Norquetiapine dihydrochloride, NET inhibitor
  • Description

    Selective NET inhibitor. Partial 5-HT1A receptor agonist.
  • Biological description

    Selective NET inhibitor. Partial 5-HT1A receptor agonist. Presynaptic α2, 5-HT2C, and 5-HT7 receptor antagonist. Quetiapine (ab120737) active metabolite. Shows antidepressant effects in vivo.
  • Purity

    > 98%
  • CAS Number

    111974-74-4
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Jaehne EJ  et al. The effect of the antipsychotic drug quetiapine and its metabolite norquetiapine on acute inflammation, memory and anhedonia. Pharmacol Biochem Behav 135:136-44 (2015). Read more (PubMed: 26047769) »
  • Björkholm C  et al. Role of concomitant inhibition of the norepinephrine transporter for the antipsychotic effect of quetiapine. Eur Neuropsychopharmacol 23:709-20 (2013). Read more (PubMed: 22732518) »
  • López-Muñoz F & Alamo C Active metabolites as antidepressant drugs: the role of norquetiapine in the mechanism of action of quetiapine in the treatment of mood disorders. Front Psychiatry 4:102 (2013). Read more (PubMed: 24062697) »

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